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PI3 — SRC

Text-mined interactions from Literome

Hakak et al., Oncogene 2000 : Activation of PI3-kinase by v-Src may be mediated by the association of the adapter protein Cbl with the p85 subunit
Castoria et al., EMBO J 2001 (Breast Neoplasms) : The Src inhibitor, PP1, prevents hormone stimulation of Akt and PI3-kinase activities in MCF-7 cells
Kanda et al., Biochem Biophys Res Commun 2003 : However, VEGFR-2, insulin receptor substrate-1, and c-Src were also involved in VEGF-A induced activation of PI3-kinase , resulting in the compensation in cells expressing kinase-inactive c-Fes
Das et al., J Biol Chem 2004 (Breast Neoplasms...) : Moreover, dn c-Src also suppressed the OPN induced phosphatidylinositol (PI) 3-kinase activity in these cells indicating that c-Src acts as master switch in regulating MEK/ERK1/2 and phosphatidylinositol 3-kinase/Akt signaling pathways
Sharma-Walia et al., J Virol 2004 : FAK was critical for the subsequent phosphorylation of Src by gB Delta TM, and Src induction was essential for the phosphorylation of phosphatidylinositol 3-kinase (PI-3K)
Lottin-Divoux et al., Cell Signal 2006 (Lymphoma) : We successively identified p95 as the nucleolin and the first signal transduction pathway specifically triggered by CD21 activation , i.e. : pp60Src activation, tyrosine phosphorylation of p95 nucleolin, its interaction with SH2 domains of p85 subunit and PI 3-kinase activation, followed by AKT-GSK-3 activations
Wang et al., J Cell Sci 2006 : It was observed that PI 3-kinase was activated either by treatment with IL-1 or by expression of either TRAF6, Src , MyD88 or dominant positive PI 3-kinase, and resulted in the formation of long filopodia-like cellular protrusions that appeared to branch at membrane sites consisting of clusters of phosphoinositide
Matsui et al., Circulation 2007 (Ischemia) : PI3-kinase is associated with vascular endothelial growth factor induced PYK2/Src complex, and inhibition of Src blocked Akt activation
Sagan et al., Biochem Biophys Res Commun 2008 (Nijmegen Breakage Syndrome) : SRC family kinases (SFKs) are involved in the activation of phosphatidylinositol-3-kinase (PI3K)
Meng et al., Br J Cancer 2009 (Adenocarcinoma...) : In addition, the Src inhibitor, PP2, blocked the phosphorylation of FAK, ERK1/2, PI3K , and Akt
Mammadova et al., BMC developmental biology 2009 : However, the tyrosine phosphorylation of p85 in fertilized eggs is not as evident as that in H2O2 activated eggs, arguing against the possibility that PI 3-kinase is activated by Src phosphorylation
Wang et al., J Cell Physiol 2011 : Engagement of G ( i/o ) -- and G ( q ) -coupled ET ( B ) receptors by ET-1 led to activation of c-Src dependent phosphoinositide 3-kinase (PI3K)/Akt and p42/p44 mitogen activated protein kinase ( MAPK ) and then activated transcription factor nuclear factor-?B ( NF-?B )
Wiedemann et al., J Biol Chem 2012 (Salmonella Infections) : Furthermore, our results revealed that the c-Src signal molecule was upstream of PI 3-kinase during the Rck mediated signaling pathway as Rck mediated PI 3-kinase activation was blocked by PP2, and PI 3-kinase inhibitor had no effect on the Src phosphorylation
Li et al., Invest Ophthalmol Vis Sci 2013 (MAP Kinase Signaling System) : Active PKCa phosphorylates Src to induce PI-3K to phosphorylate AKT that subsequently activates the ERK1/2 cascade to stimulate goblet cell proliferation
Kotelevets et al., J Biol Chem 1998 (Colonic Neoplasms) : Similar effects were observed in ts-srcMDCK kidney epithelial cells transformed by a v-Src temperature-sensitive mutant : ( i ) PAF and wortmannin exerted additive inhibitory effects on Src induced invasion and ( ii ) activated and dominant negative forms of p110alpha PI3'-K , respectively, amplified and abrogated the Src- and HGF dependent invasiveness of parental and ts-srcMDCK cells