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EIF2AK2 — RELA

Text-mined interactions from Literome

Gil et al., Mol Cell Biol 1999 : Biochemical analysis and transient assays revealed that PKR expression by a VV vector induced NF-kappaB binding and transactivation
Zamanian-Daryoush et al., Mol Cell Biol 2000 : Taken together, these results demonstrate that PKR dependent dsRNA induction of NF-kappaB is mediated by NIK and IKK activation
Bandyopadhyay et al., J Immunol 2000 : Because we have previously shown that the dsRNA activated kinase PKR mediates dsRNA induction of NF-kappaB , we used murine aortic endothelial ( MuAE ) cells isolated from wild-type and PKR-null mice to investigate the role of PKR in the induction of E-selectin expression by dsRNA ( pIC ) and TNF-alpha
Gil et al., Oncogene 2000 : We have recently described that induction of NF-kappa B by PKR is involved in apoptosis commitment ... Expression by VV recombinants of IKK1 or IKK2 dominant negative mutants together with PKR showed inhibition of PKR induced NF-kappa B activation, as measured both by gel shift and luciferase reporter assays
Bonnet et al., Mol Cell Biol 2000 : PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex ... Here, we have studied the ability of PKR to activate NF-kappaB in a reporter assay and have shown for the first time that two catalytically inactive PKR mutants, PKR/KR296 and a deletion mutant ( PKR/Del42 ) which lacks the potential eIF2alpha binding domain, can also activate NF-kappaB ... This result indicated that NF-kappaB activation by PKR does not require its kinase activity and that it is independent of the PKR-eIF2alpha relationship
Iordanov et al., Mol Cell Biol 2001 : It has been proposed that PKR plays an essential role in the activation of NF-kappaB by dsRNA ... Here we present evidence that the dsRNA induced NF-kappaB activity and the expression of beta interferon and inflammatory cytokines do not require either PKR or RNase L
Blair et al., Diabetes 2001 : These results suggest that 1 ) NF-KB activation is required for dsRNA + IFN-gamma induced iNOS expression, 2 ) PKR is not required for either dsRNA induced NF-kappaB activation or dsRNA + IFN-y induced iNOS expression by islets, and 3 ) PKR is not required for dsRNA + IFN-gamma induced inhibition of glucose stimulated insulin secretion by islets
Ishii et al., Oncogene 2001 (Cell Transformation, Neoplastic) : For example, PKR induces I kappa B alpha kinase (IKK) activity and I kappa B alpha phosphorylation leading to the induction of NF-kappa B-mediated gene transcription ... Recent findings suggested that NF-kappa B activation by PKR does not require the catalytic activity of the kinase ... We also show that the effects of PKR mutants on IKK and NF-kappa B activation are independent of cell transformation but are dependent on the amount of the mutant PKR proteins expressed in cells
Gil et al., Oncogene 2001 : We have previously shown that induction of NF-kappaB by PKR is involved in apoptosis commitment and this process is mediated through activation of the IKK complex ... To gain insights into the mechanism of activation of NF-kappaB by PKR , we have analysed the domains of PKR involved in IKK activation and subsequent NF-kappaB induction ... An inactive PKR mutant ( K296R ), was unable to induce NF-kappaB activation despite full expression of the protein in a wide range of concentrations, as defined by Western blot, EMSA, IKK kinase activity and NF-kappaB transactivation assays
Deb et al., J Immunol 2001 : RNA dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1 independent pathway
D'Acquisto et al., Science's STKE : signal transduction knowledge environment 2001 : The activation of the transcription factor nuclear factor kappa B (NF-kappaB) by PKR has been shown to account for the host antiviral response ... We summarize the most recent findings on the molecular mechanisms leading to the activation of NF-kappaB by PKR and discuss three major unanswered questions
Williams et al., Science's STKE : signal transduction knowledge environment 2001 : This review will focus on the role of PKR in nuclear factor kappa B (NF-kappaB) and mitogen activated protein kinase ( MAPK ) pathways, because these have been the subjects of a series of publications over the past year that have reported conflicting findings
Jiang et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Kinase inactive mutants of TAK1 ( TAK1DN ) and PKR ( PKRDN ) inhibit poly ( dI.dC ) -induced TLR3 mediated NFkappaB activation, suggesting that both of these kinases play important roles in this pathway
Gil et al., Mol Cell Biol 2004 : The double stranded RNA ( dsRNA ) -dependent protein kinase PKR activates NF-kappa B via the I kappa B kinase (IKK) complex, but little is known about additional molecules that may be involved in this pathway
Taddeo et al., J Virol 2004 : Earlier we reported that NF-kappaB is activated by protein kinase R (PKR) in herpes simplex virus 1-infected cells
Frémont et al., Life Sci 2006 (Lymphoma, B-Cell) : PKR is also involved in the activation of nuclear factor kappaB (NFkappaB) through activation of the IkappaB kinase complex
Kårehed et al., Mol Immunol 2007 : Our results suggest that IFN-gamma induced increase of FcgammaRI expression requires the integration of two signalling events : PKR dependent Stat1 serine 727 phosphorylation, and activation of NFkappaB
Delgado André et al., Blood Cells Mol Dis 2008 : The transcription factor NF-kappaB is activated by PKR through phosphorylation and subsequent degradation of its inhibitor I-kappaBbeta
Eley et al., Cancer Chemother Pharmacol 2009 (Neoplasms, Experimental) : These results suggest that inhibitors of PKR may be useful therapeutic agents against tumours showing increased expression of PKR and constitutive activation of NF-kappaB , and may also prove useful in sensitising tumours to standard chemotherapeutic agents
Myskiw et al., J Virol 2009 : PKR dependent activation of p38 and NF-kappaB was required for vaccinia virus induced INHBA expression, whereas induction of TNF-alpha required only PKR dependent NF-kappaB activation
McAllister et al., J Virol 2010 : Furthermore, protein kinase PKR and mitochondrial adapter IPS-1 were required for maximal C ( ko ) -mediated IFN-beta induction, which correlated with the PKR mediated enhancement of mitogen activated protein kinase and NF-kappaB activation
Lin et al., Cytokine 2010 : We next revealed that PKR activity mediates LMP1 enhanced NF-kappaB nuclear translocation resulting in cytokine induction
Kumar et al., Proc Natl Acad Sci U S A 1994 : We present direct evidence that PKR can phosphorylate I kappa B-alpha ( MAD-3 ) and activate NF-kappa B DNA binding activity in vitro
Rager et al., J Virol 1998 (Vaccinia) : Furthermore, dsRNA treatment of Ramos cells resulted in the activation of PKR and in vivo activation of the NF-kappaB complex
Paludan et al., J Gen Virol 1998 (Herpes Genitalis) : The effect of the NF-kappaB activation inhibitor was not mediated through inhibition of the production of interferon regulatory factor (IRF)-1 or of TNF-alpha itself, and a possible alternative mechanism of activation of NF-kappaB through virus induced activation of the kinase PKR was also ruled out
Cheshire et al., J Biol Chem 1999 : The double stranded RNA dependent kinase PKR is IFN-inducible and has been implicated in the activation of NF-kappaB ; therefore, we examined the possibility that PKR may play a role in the synergistic activation of NF-kappaB during TNF-alpha/IFN-gamma cotreatment ... The PKR inhibitor 2-aminopurine ( 2-AP ) inhibited TNF-alpha/IFN-gamma induced NF-kappaB nuclear translocation in neuronal derived cells but not in endothelial cells