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PARG — PARP2
Text-mined interactions from Literome
Woon et al., Curr Med Chem 2005
:
Fifthly,
PARP activity can be
inhibited in cells by inhibition of
poly(ADP-ribose)-glycohydrolase ( PARG ) ; will this be a viable strategy for future drug design ?
Botta et al., Biochemistry 2010
:
The presence of the REG/MTS raises the possibility that
PARG activity is
regulated by interactions of
PARP-1 and -2 and other proteins at this site, raises interesting questions concerning mitochondrial PARG because MTS residues are often removed after transport, and offers a potentially novel site for drug targeting of PARG
Grady et al., J Virol 2012
(Herpes Simplex) :
This work demonstrates that HSV-1 infection results in changes to NAD ( + ) metabolism by PARP-1/2 and PARG, and as PAR chain accumulation can induce caspase independent apoptosis, we speculate that the decrease in
PARG levels
enhances the auto-PARylation mediated inhibition of
PARP , thereby avoiding premature death of the infected cell