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IGF1 — NGF
Text-mined interactions from Literome
Jamen et al., J Neurochem 2002
(MAP Kinase Signaling System) :
NGF and
IGF-1 increased endogenous PAC1 mRNA levels, and the
NGF induced up-regulation is the
result of an increase in transcription from PAC1 promoter instead of an increase in mRNA stability
Zhang et al., Regul Pept 2012
(Cystitis) :
Regulation of
IGF-1 but not TGF-ß1 by
NGF in the smooth muscle of the inflamed urinary bladder ... The effect of NGF on regulating IGF-1 expression was further confirmed in bladder smooth muscle culture showing that exogenous
NGF increased the mRNA level of
IGF-1 after 30 min to 1 h stimulation
Burgess et al., J Biol Chem 1987
:
7 S
nerve growth factor , but not beta-nerve growth factor, also
inhibited 125I-IGF-I binding
Fernyhough et al., Brain Res 1993
:
Specific anti-NGF antiserum inhibited the regenerative response to NGF but failed to block the response to IGF-I, supporting the view that
IGF-I was
acting directly on sensory neurones rather than stimulating
NGF production by non-neuronal cells