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PLAU — SPHK2

Text-mined interactions from Literome

Young et al., Mol Cancer Res 2009 (Glioblastoma...) : Inhibition of SphK blocked basal expression of uPA and uPAR, as well as glioma cell invasion ; however, overexpression of SphK did not augment S1P receptor mediated enhancement of uPA activity or invasion
Liu et al., Int J Colorectal Dis 2012 (Colonic Neoplasms...) : Moreover, SphK1 was required for the production of MMP-2/9 and uPA in tumor cells, which was suppressed by ERK1/2 inhibitor U0126, but enhanced by the p38 MAPK inhibitor SB203580