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JUN — TCF7
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes transcription factor complex:
transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3)
Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
Text-mined interactions from Literome
Chen et al., Mol Carcinog 1999
:
Our previous studies have indicated that UVB induced c-fos expression may play a key role in UVB induced activation of the activator protein-1
transcription factor and EGCG inhibited, UVB induced
activation of
AP-1 in HaCaT cells
Famulski et al., Cell Death Differ 1999
:
We propose that ( i ) the up-regulation of an acidic nuclease activity is governed by a regulatory pathway different from that responsible for AP-1 factor induction, caspases activation and intracellular acidification, and ( ii ) activation of an acidic nuclease does not cause any deleterious effects when
AP-1 transcription factor induction , caspases activation and intracellular acidification are down-regulated
Troussard et al., Oncogene 2000
(Glioblastoma) :
The integrin linked kinase (ILK) induces an invasive phenotype via
AP-1 transcription factor dependent upregulation of matrix metalloproteinase 9 (MMP-9)
Sodhi et al., J Interferon Cytokine Res 2002
:
Additionally, phosphorylation of JNK and
activation of the
transcription factor ,
c-Jun , were also noted in response to MCP-1 treatment
Ventura et al., Mol Cell Biol 2003
(MAP Kinase Signaling System) :
The JNK signal transduction pathway is therefore essential for
AP-1 transcription factor regulation in cells exposed to TNF
Chen et al., Arterioscler Thromb Vasc Biol 2003
(Arteriosclerosis) :
Electrophoretic mobility shift assay demonstrated that both GBE and probucol inhibited
transcription factor nuclear factor-kappaB activation in TNF-alpha stimulated HAECs ( 55.2 % and 65.6 % inhibitions, respectively ) but only GBE could
inhibit the TNF-alpha stimulated
activator protein 1 activation ( 45.1 % inhibition, P < 0.05 )
Kinser et al., J Toxicol Environ Health 2004
(Inflammation) :
c-Fos, Fra-,
c-Jun , and JunB, components of the activator protein-1 (AP-1) transcription factor complex, were
induced by DON as well as another
transcription factor , NR4A1
Hwang et al., FEBS Lett 2005
:
AP-1 activation suppressed the expression of Sox-9, a major
transcription factor regulating type II collagen expression
Sahambi et al., Birth Defects Res A Clin Mol Teratol 2006
(Abnormalities, Drug-Induced) :
We hypothesize that oxidative stress and
activation of a redox-sensitive
transcription factor ,
activator protein-1 (AP-1) , are early indicators of embryonic stress in response to a teratogenic insult ... We hypothesize that oxidative stress and
activation of a redox-sensitive
transcription factor ,
activator protein-1 (AP-1), are early indicators of embryonic stress in response to a teratogenic insult
Tu et al., Am J Physiol Cell Physiol 2007
:
Involvement of oxidants and
AP-1 in angiotensin II-activated NFAT3
transcription factor
Smart et al., Hepatology 2006
(Carbon Tetrachloride Poisoning...) :
JunD is a profibrogenic
transcription factor regulated by
Jun N-terminal kinase independent phosphorylation
Weinberg et al., Neuroscience 2007
:
Differential basal and stress induced expression patterns of the fra-2 and c-fos genes are likely to have important functional consequences for
AP-1 transcription factor dependent
regulation of neural plasticity
Lin et al., Inflamm Bowel Dis 2008
(Crohn Disease) :
Probiotic L. reuteri suppressed TNF transcription by inhibiting activation of MAP kinase
regulated c-Jun and the
transcription factor ,
AP-1
Salisbury et al., Mol Endocrinol 2009
:
Together, these results indicate that GnRH regulation of
Jun transcription
requires a functional interaction between
TCF/LEF and beta-catenin and that alteration of either impacts expression of JUN downstream targets such as Cga
Jung et al., Biofactors 2008
:
Matrine
inhibited PMA induced activation of the
AP-1 promoter, an important nuclear
transcription factor in MMP-1 expression
Hsieh et al., Journal of neuroinflammation 2010
(MAP Kinase Signaling System) :
ROS production leads to
activation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and
c-Jun-N-terminal kinase (JNK) and then activation of the NF-?B
transcription factor
Chae et al., Biosci Biotechnol Biochem 2011
:
And, it
inhibited DNA binding activity of
activator protein-1 (AP-1) , a
transcription factor of MMP-1 and downstream of ERK and JNK
Hwang et al., Arthritis Res Ther 2012
(Arthritis, Rheumatoid) :
Importantly, the preferential induction of IL-34 rather than M-CSF by TNFa in RAFLS was mediated by the
transcription factor nuclear factor kappa B ( NF-?B ) and
activation of
c-Jun N-terminal kinase (JNK)
Hattori et al., Am J Physiol 1993
(Acute-Phase Reaction...) :
These findings demonstrate the complexity of
AP-1 hepatic
transcription factor responses to humoral regulators with direct hepatocellular effects
Erkel et al., J Antibiot (Tokyo) 1996
:
In reporter gene assays nidulal ( 1 ) preferentially activated the
transcription factor complex
AP-1 mediated expression of secreted alkaline phosphatase in COS-7 cells
Manna et al., J Immunol 1998
:
TNF induced
activation of another nuclear
transcription factor ,
AP-1 , was suppressed by IL-13
Chen et al., J Biol Chem 1998
:
The effects of UVB irradiation on
transcription factor activator protein-1 (AP-1) DNA binding and
AP-1 transactivation were studied in a human keratinocyte cell line, HaCaT