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CD44 — MAPK13
Text-mined interactions from Literome
Monaghan et al., J Pathol 2000
(Astrocytoma...) :
Up-regulation of
CD44 by EGF is also
prevented by the transcriptional inhibitor actinomycin D ( 5 microg/ml ) and by blocking the
MAP kinase ( MAPK ) pathway using the MEK inibitor U0126 ( 100 microM )
Fujita et al., FEBS Lett 2002
:
Engagement of
CD44 either by its natural ligand hyaluronan or a specific antibody on a cell line induced tyrosine phosphorylation and activation of focal adhesion kinase ( FAK ), which then associated with phosphatidylinositol 3-kinase (PI3K) and
activated mitogen activated protein kinase at its downstream
Gee et al., J Immunol 2002
:
We demonstrate the
involvement , at least in part, of p38
MAPK in TNF-alpha induced
CD44 expression in both monocytes and promonocytic THP-1 cells
Roscic-Mrkic et al., Blood 2003
:
By specifically reducing CD44 expression using RNA interference we were able to demonstrate that the p44/p42
MAPK activation by RANTES
requires a high level of
CD44 expression ... Here we show that silencing of
CD44 in HeLa-CD4 cells
prevents the activation of p44/p42
MAPK and leads to a substantial reduction in HIV-1 infectivity enhancement by RANTES
Gee et al., J Biol Chem 2003
:
Furthermore, p38 mitogen activated protein kinase (
MAPK ) activation was
required for LPS- and TNF-alpha induced, but not IL-10 induced,
CD44-HA binding in normal monocytes ... Subsequently, TNF-alpha mediated p38
MAPK activation
induced sialidase activity and
CD44-HA binding ... Taken together, our results suggest that TNF-alpha induced p38
MAPK activation may
regulate the induction of functionally active HA-binding form of
CD44 by activating sialidase in LPS stimulated human monocytic cells
Singh et al., Glycobiology 2006
(Colonic Neoplasms) :
Peanut lectin stimulates proliferation of colon cancer cells by interaction with glycosylated
CD44v6 isoforms and consequential
activation of c-Met and
MAPK : functional implications for disease associated glycosylation changes
Kim et al., Mol Immunol 2008
(Dermatitis, Allergic Contact...) :
CD44 mediated effect of antigen on phosphorylation of ERK,
p38MAPK , ROS production, secretion of beta-hexosaminidase, and histamine release