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IL1B — RNF19A

Text-mined interactions from Literome

Floyd et al., Proc Soc Exp Biol Med 1999 (Alzheimer Disease...) : iNOS induction involves activation by phosphorylation of the MAP kinase p38 and can be induced in cultured astrocytes by IL-1beta or H2O2
Floyd et al., Ann N Y Acad Sci 2000 : In rat primary astrocytes p38 activation by the pro-inflammatory cytokine IL-1 beta , as well as by H2O2, was significantly suppressed by PBN
Paraskevas et al., Ann Surg 2001 (Cadaver) : In the cytokine stimulation studies, IL-1 beta stimulated p38 activation in a dose dependent manner, while JNK was relatively unaffected
Park et al., Mol Pharmacol 2002 : Moreover, IL-1 beta stimulation of the cells caused the phosphorylation of p38 and extracellular signal regulated kinase ( ERK ), and IL-1 beta induced COX-2 expression was inhibited by the pretreatment of WISH cells with a p38 inhibitor, in contrast ERK upstream inhibitor had no effect
Pinteaux et al., J Neurochem 2002 : In comparison, IL-1beta induced the release of PGE2, IL-6 and activated NF-kappaB, p38 , JNK and ERK1/2 in mixed glial cultures, but failed to induce any of these responses in microglial cell cultures
Englesbe et al., J Vasc Surg 2004 : We further addressed the role of the mitogen activated protein kinase p38 , which is activated by PDGF-BB and by IL-1beta
Migita et al., Clin Exp Immunol 2004 (Arthritis, Rheumatoid...) : A77 1726 partially suppressed IL-1beta induced ERK1/2 and p38 kinase activation
Toh et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : IL-1beta rapidly up-regulated MKP-1, coinciding with reciprocal down-regulation of ERK, JNK, and p38 MAPK phosphorylation
Zhai et al., Br J Pharmacol 2004 (MAP Kinase Signaling System) : p38 , JNK and ERK MAPKs were activated by IL-1beta in a time dependent manner, with peak activation time at 30, 60 min and at 6 h, respectively ... SP600125 ( 20 microM ) had no effect on IL-1beta induced ERK and p38 phosphorylation
Størling et al., Endocrinology 2005 : Activation of p38 and ERK in response to IL-1beta was also dependent on L-type Ca ( 2+ ) influx
Rossa et al., J Interferon Cytokine Res 2006 (MAP Kinase Signaling System) : MKK3/6-p38 MAPK signaling is required for IL-1beta and TNF-alpha induced RANKL expression in bone marrow stromal cells
Tew et al., J Biol Chem 2006 : Furthermore stimulation of chondrocyte p38 MAPK activity with interleukin-1beta resulted in increased levels of SOX9 mRNA, and this was again dependent on the absence of actin stress fibers in the cells
Chen et al., Biochem Pharmacol 2007 (Lung Neoplasms) : Pretreatment of cells with tangeretin inhibited IL-1beta induced p38 MAPK, JNK, and AKT phosphorylation and the downstream activation of NF-kappaB
Lewthwaite et al., Int Immunopharmacol 2007 (Inflammation) : Selective inhibitors of p38 ( mapk ) ( SB203580 ) or of MEK1/2, the direct upstream activator of ERK1/2 ( PD98059 ), reduced the synthesis of IL-1beta , TNFalpha, IL-6 and IL-8 induced by either the chaperonins or LPS
Netea et al., Proc Natl Acad Sci U S A 2008 : Whereas the induction of TNFalpha, IL-1beta , and IL-6 by IL-32 is mediated by p38-MAPK , IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic, caspase-3 dependent mechanisms
Choi et al., Phytother Res 2009 (Arthritis, Rheumatoid) : IL-1beta induced JNK and p38 activation was inhibited by LF, and LF significantly reduced the DNA binding activity of transcription factors NF-kappaB and AP-1
Tsai et al., J Biomed Sci 2009 (Disease Progression...) : Finally, TGF-beta was able to induce CTGF, and in turn CTGF represses PAR-2 expression by inhibiting IL-1beta induced phospho-p38 level
Guan et al., J Biol Chem 1997 : Our current studies demonstrate that IL-1beta produces a rapid increase in p38 mitogen activated protein kinase ( MAPK ) phosphorylation and activation
Guan et al., J Biol Chem 1998 : We reported previously that IL-1beta rapidly activates the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and p38 mitogen activated protein kinase ( MAPK ) and also induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production ... Overexpression of the kinase-dead form of MKK3 or MKK6 demonstrated that either of these two mutant kinases inhibited IL-1beta induced p38 MAPK phosphorylation and Cox-2 expression but not JNK/SAPK phosphorylation and activation