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PRKAG1 — SOCS3
Text-mined interactions from Literome
Ko et al., Diabetes 2009
(Diabetic Angiopathies...) :
Acute physiological elevation of IL-6 suppressed glucose metabolism and caused insulin resistance by increasing SOCS3 and via
SOCS3 mediated inhibition of insulin receptor substrate (IRS)-1 and possibly
AMPK in heart
Kim et al., Diabetologia 2012
(Insulin Resistance) :
IL-6 induced STAT3 transactivation and
SOCS3 production were significantly
repressed by metformin, adenoviral constitutively active
AMPK ( Ad-CA-AMPK ), and adenoviral SHP ( Ad-SHP ), but not in Shp knockdown, or with the adenoviral dominant negative form of AMPK ( Ad-DN-AMPK )
Wan et al., PloS one 2012
:
Treatment of cultured epididymal adipose tissue ( eWAT ) with IL-6 ( 150 ng/ml ) increased the phosphorylation of
AMPK , ACC and STAT3 and
induced SOCS3 mRNA levels while decreasing PEPCK and PDK4 mRNA