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FYN — PTGS2

Text-mined interactions from Literome

Kang et al., Carcinogenesis 2009 (MAP Kinase Signaling System) : In this study, we found that Fyn , one of the members of the non-receptor protein tyrosine kinase family, was required for ultraviolet ( UV ) B-induced cyclooxygenase-2 (COX-2) expression, and caffeic acid suppressed UVB induced skin carcinogenesis by directly inhibiting Fyn kinase activity ... Pharmacological Fyn kinase inhibitor ( 3- ( 4-chlorophenyl ) 1- ( 1,1-dimethylethyl ) -1H-pyrazolo [ 3,4-d ] pyrimidin-4-amine and leflunomide ) data also revealed that Fyn is involved in UVB induced COX-2 expression mediated through the phosphorylation of MAPKs in JB6 P+ cells
Cho et al., Cell Physiol Biochem 2012 (MAP Kinase Signaling System) : Among the signaling components of FceRI, Fyn , PI 3-kinase, Akt, and p38 MAPK positively mediated the COX-2 expression
Wang et al., Zhong Xi Yi Jie He Xue Bao 2012 (Adenocarcinoma...) : To study the effect of Feiyanning Decoction (FYN) , a compound traditional Chinese medicine, on expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activated by tumor necrosis factor-a (TNF-a) in human lung adenocarcinoma epithelial cell line ( A549 ) ... FYN significantly inhibited TNF-a induced expression of iNOS and COX-2 compared with the control group in A549 cells ( P < 0.01, P < 0.01 ) ... These results suggest that FYN inhibits iNOS and COX-2 activation induced by TNF-a, therefore, it is expected to develop a new strategy to treat lung cancer