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CNTN2 — IL2
Text-mined interactions from Literome
Aqeilan et al., Biochem J 2003
:
Indeed, a dramatic repression of nuclear
Tax protein expression was
induced following treatment of HUT-102 cells with
IL-2-Bax , similar to what occurs following serum deprivation of these cells
Fung et al., Oncogene 2005
:
Microarray analyses revealed several genes, including il-5, il-9 and il-13, are uniquely upregulated by
IL-2 in the
presence of
Tax
Wano et al., Proc Natl Acad Sci U S A 1988
:
Tax induction of the
interleukin 2 gene is synergistically amplified by mitogens that augment cytoplasmic levels of calcium
Lanoix et al., Oncogene 1994
(Cell Transformation, Viral) :
The
Tax protein of HTLV-I, a positive transcriptional activator of HTLV-I gene expression, is a viral oncogene that also
increases transcription of cellular genes including GM-CSF, IL-2R alpha and
IL-2
Seeler et al., Virology 1993
:
Tax activation of the
IL-2 receptor and the HIV-1 LTR is mediated through NF-kappa B motifs
Good et al., EMBO J 1996
:
In the present study, we demonstrate that neither NF-kappa B/Rel nor CREB/ATF is sufficient for
Tax mediated activation of the
IL-2 promoter ... Transient transfection studies demonstrate that the in vivo expressed NF-ATp binds to the CD28RE probe and enhances
Tax mediated activation of this critical
IL-2 enhancer ... Together, these results suggest a novel mechanism of
Tax mediated activation of the
IL-2 gene, which involves the induction of NF-AT containing CD28RE binding complexes
Papiez et al., Postepy Hig Med Dosw 1995
(Leukemia, T-Cell) :
Tax increases the expression of cell protooncogenes as well as lymphokines, among others
IL-2 and its receptor