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RAC1 — SLC22A3

Text-mined interactions from Literome

Bakin et al., J Cell Sci 2002 (Cell Transformation, Neoplastic) : Finally, dominant negative Rac1N17 blocked TGFbeta induced activation of the p38MAPK pathway and EMT , suggesting that Rac1 mediates activation of the p38MAPK pathway
Patel et al., Am J Nephrol 2006 : Inhibition of EMT in HK2 cells with these statins resulted in a reduction of RhoA and Rac1 activation in both the cytoplasmic and membrane bound forms, in preservation of the expression of the epithelial cell markers E-cadherin and cytokeratin-19, and in a decrease in Fn-EDA expression, a marker for the myofibroblast phenotype
Nelson et al., J Cell Biochem 2008 : We show here that cells treated with MMP-3 or induced to express Rac1b spread to cover a larger surface, and that this induction of cell spreading is a requirement of MMP-3/Rac1b induced EMT
Tang et al., Hepatology 2010 (Carcinoma, Hepatocellular...) : Conclusion : EIF5A2 plays an important role in HCC invasion and metastasis by inducing EMT , as well as stimulating cytoskeleton rearrangement through activation of RhoA and Rac1
Stallings-Mann et al., Sci Transl Med 2012 (Adenocarcinoma...) : We show that expression of mouse Rac1b in lung epithelial cells of transgenic mice stimulated EMT and spontaneous tumor development and that activation of EMT by MMP induced expression of Rac1b gave rise to lung adenocarcinoma in the transgenic mice through bypassing oncogene induced senescence
Lv et al., Int J Biochem Cell Biol 2013 : These findings elaborated that Rac1/PAK1 signaling contributed to high glucose induced podocyte EMT via promoting ß-catenin and Snail transcriptional activities, which could be a potential mechanism involved in podocytes injury in response to stimuli under diabetic conditions