Gene interactions and pathways from curated databases and text-mining

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CA2 — STIM1

Text-mined interactions from Literome

Bleich et al., Pflugers Arch 1999 : As before, STIM enhanced [Ca2+ ] i
Naghdi et al., J Cell Sci 2010 : Mitochondrial Ca2+ uptake and not mitochondrial motility is required for STIM1-Orai1 dependent store operated Ca2+ entry
Berry et al., Prostate 2011 (Calcium Signaling) : Reduced STIM1 expression in prostate stromal cells led to a reduction in basal Ca2+ levels, the amount of Ca2+ released by thapsigargin and a reduction in store filling following TG-induced store depletion
Hulot et al., Circulation 2011 (Calcium Signaling...) : A potential route is store operated Ca2+ entry, a drug-inducible mechanism for Ca2+ signaling that requires stromal interaction molecule 1 (STIM1)
Pham et al., Cell Calcium 2012 : Our results suggest that Stim1 oligomerization and puncta formation may be additionally regulated either by local Ca2+ levels near the ER membrane or by as yet unidentified Ca2+ dependent proteins interacting with the cytoplasmic domains of Stim1
Dickson et al., Proc Natl Acad Sci U S A 2012 (Calcium Signaling) : Orai-STIM mediated Ca2+ release from secretory granules revealed by a targeted Ca2+ and pH probe
Lee et al., Biochem J 2013 : STIM1 negatively regulates Ca2+ release from the sarcoplasmic reticulum in skeletal myotubes ... These results suggest that STIM1 negatively regulates Ca2+ release from the SR through the direct interaction of the STIM1 C-terminus with DHPR, and that STIM1 is involved in both ECC and SOCE in skeletal muscle
Zhang et al., Mol Cell Biol 2013 (Calcium Signaling) : Mechanisms of STIM1 Activation of Store Independent Leukotriene C4-Regulated Ca2+ Channels