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IFI44 — IL1A
Text-mined interactions from Literome
Matthews et al., Cytokine 1999
(Thymoma...) :
Interleukin 1 (IL-1) activates
p42/p44 and p38 mitogen activated protein kinases ( MAP kinases ) in target cells
Miwa et al., Endocrinology 1999
:
IL-1alpha time-dependently
stimulated the phosphorylation of both
p42/p44 mitogen activated protein ( MAP ) kinase and p38 MAP kinase
Vela et al., Mol Cell Neurosci 2002
:
Regarding intracellular signaling,
IL-1beta activated the p38 mitogen activated protein kinase ( MAPK ) but not the p42/p44 MAPK and, when combined with growth factors, intensified p38 activation but
inhibited the growth-factor induced
p42/p44 activation
Lee et al., World J Gastroenterol 2006
(MAP Kinase Signaling System) :
Based on these results,
IL-1beta induced
p44/42 MAP kinase activation is mediated by the Gi protein, tyrosine kinase, phospholipase C (PLC) and PKC
Eda et al., Rheumatol Int 2011
(MAP Kinase Signaling System) :
IL-1ß and TNF-a
activated the intracellular mitogen activated protein kinases ( MAPKs ) :
p44/42 MAPK, p38, and c-Jun N-terminal kinase (JNK) as well as nuclear factor-?B ( NF-?B ) in osteoblasts