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ESR1 — NOS3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: NOS3 — ESR1 (physical association, anti bait coimmunoprecipitation) Li et al., Proc Natl Acad Sci U S A 2007*
• IRef Dip Interaction: Complex of SRC-NOS3-ESR1 (anti bait coimmunoprecipitation) Li et al., Proc Natl Acad Sci U S A 2007*

Text-mined interactions from Literome

Shaul et al., Steroids 1999 : These findings indicate that the acute effects of estrogen on both endothelial and airway epithelial eNOS are mediated by ERalpha functioning in a novel, nongenomic manner to activate the enzyme via calcium dependent, MAP kinase dependent mechanisms
Tan et al., Cardiovasc Res 1999 : Estrogen receptor-alpha gene transfer into bovine aortic endothelial cells induces eNOS gene expression and inhibits cell migration ... Our results suggest that the atheroprotective effects of estrogen may in part be mediated by ER alpha induced upregulation of eNOS gene expression and maintenance of endothelial cell function and integrity
Shaul et al., Semin Perinatol 2000 : Thus, the acute effect of estrogen on eNOS is mediated by ERalpha functioning in a novel, nongenomic manner to activate the enzyme via calcium dependent, MAP kinase dependent mechanisms
Simoncini et al., J Clin Endocrinol Metab 2000 : Indeed, raloxifene induced NO production is due to an estrogen receptor dependent acute stimulation of eNOS enzymatic activity
Nuedling et al., FEBS Lett 2001 : R, R-THC inhibited activation of iNOS/eNOS promoter-luciferase reporter constructs ( iNOS/eNOS-Luc ) in a dose dependent fashion in COS7 cells selectively transfected with ERbeta, but failed to influence ERalpha mediated increase of iNOS/ eNOS-Luc
McNeill et al., Stroke 2002 (Body Weight) : Estrogen receptor activation in cerebrovascular tissue results in increased eNOS activity and protein levels
Simoncini et al., Arterioscler Thromb Vasc Biol 2003 : By interacting with phosphatidylinositol 3-kinase (PI3K), estrogen receptor (ER) alpha leads to activation of protein kinase Akt and to subsequent increase in endothelial nitric oxide synthase activity
Harada et al., Pediatr Res 2004 (Reperfusion Injury) : We conclude that this protection may in part be due to the E(2)/ER-alpha mediated activation of eNOS
Kakui et al., Mol Hum Reprod 2004 : These data suggest the possibility that both ERalpha and ERbeta are involved in the estrogen associated regulation of eNOS gene expression in the human myometrium
Xia et al., Endocrinology 2004 (Neuroblastoma) : These results demonstrate that E2-stimulated NO production occurs via estrogen receptor mediated activation of the constitutive NOSs, neuronal NOS and eNOS
Gingerich et al., Endocrinology 2005 : We used the selective ERalpha agonist, propyl-pyrazole-triol ( 10 nm ), and antagonist, methyl-piperidino-pyrazole ( 1 microm ), to exclude the possibility that ERalpha is involved in the E2-induced increase in eNOS and nNOS in the PVN
Anter et al., Circ Res 2005 : These findings suggest p38 MAP kinase mediated eNOS activation requires ERalpha and these data uncover a new mechanism of ERalpha activation that has broad implications for NO bioactivity and endothelial cell phenotype
Sitges et al., Int J Cardiol 2005 (Coronary Artery Disease) : NOS III mRNA expression was only correlated to ER alpha expression, suggesting that NOS III activation could be more mediated by ER alpha
Kumar et al., Mol Endocrinol 2007 : In endothelial cells, the disruption of ER alpha-G alpha i interaction prevents estradiol induced nitric oxide synthase activation and the resulting attenuation of monocyte adhesion that contributes to estrogen related cardiovascular protection
Liu et al., J Agric Food Chem 2008 : Distinct effects of naringenin and hesperetin on NO production also imply that ERalpha might play the major role in estrogen induced eNOS expression
Cignarella et al., J Pharmacol Exp Ther 2009 (Diabetes Mellitus, Experimental...) : Distinct roles of estrogen receptor-alpha and beta in the modulation of vascular inducible nitric-oxide synthase in diabetes
Figtree et al., Int J Cardiol 2010 (Coronary Artery Disease) : Estrogen receptor alpha (ERalpha) mediates beneficial actions on endothelial nitric oxide synthase (eNOS) and cholesterol metabolism
Tamura et al., J Hypertens 2009 (Hypertension...) : The regulation of eNOS was mediated by ERalpha
Hwang et al., Toxicol Appl Pharmacol 2011 : Puerarin induced eNOS phosphorylation required estrogen receptor ( ER ) -mediated phosphatidylinositol 3-kinase (PI3K)/Akt signaling and was reversed by AMP activated protein kinase (AMPK) and calcium/calmodulin dependent kinase II ( CaMKII ) inhibition