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COMMD1 — HIF1A

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HIF1A — COMMD1 (physical association, affinity chromatography technology) van de Sluis et al., PloS one 2009*

Text-mined interactions from Literome

van de Sluis et al., Mol Cell Biol 2007 : Consistent with these observations, COMMD1 physically associates with HIF-1alpha and inhibits HIF-1alpha stability and HIF-1 transactivation in vitro ... Consistent with these observations, COMMD1 physically associates with HIF-1alpha and inhibits HIF-1alpha stability and HIF-1 transactivation in vitro
van de Sluis et al., Cell cycle (Georgetown, Tex.) 2007 : In line with these in vivo data, in vitro studies showed that reduced COMMD1 expression caused increased HIF-1alpha protein stability and HIF-1 activity
van de Sluis et al., PloS one 2009 : Here we characterized the mechanism by which COMMD1 regulates HIF-1alpha protein degradation ... Inhibition of HSP90 activity with 17-Allylamino-17-demethoxygeldanamycin ( 17-AAG ) increased COMMD1 mediated HIF-1alpha degradation independent of ubiquitin and pVHL
van de Sluis et al., J Clin Invest 2010 (Lung Neoplasms...) : COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion