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ADCY10 — PI3
Text-mined interactions from Literome
Niwa et al., Life Sci 2000
:
Both prostaglandin E2 ( PGE2 ) and wortmannin, an inhibitor of phosphatidyl inositol 3-kinase (PI-3K), inhibited neutrophil aggregation, whereas dbcAMP, a cell permeable analog of cyclic AMP, did not, confirming that PGE2 causes neutrophil aggregation probably through
PI-3K inhibition rather than
activation of
adenylate cyclase
Hardy et al., Blood 2004
(Calcium Signaling) :
This potentiation is mediated by 2 mechanisms : inhibition of
adenylate cyclase and
activation of
phosphatidylinositol 3 (PI 3)-kinase
Carini et al., Gastroenterology 2004
(Reperfusion Injury) :
In the cells treated with CGS21680,
PI3K activation was
prevented either by inhibiting
adenylate cyclase and PKA with, respectively, 2,5-dideoxyadenosine and H89 or by blocking Galphai-protein and Src tyrosine kinase with, respectively, pertussis toxin and PP2
Hildebrand et al., Cell communication and signaling : CCS 2012
:
PMT inhibits the production of IL-12p40 by Gai mediated inhibition of
adenylate cyclase and cAMP accumulation and by Gß? mediated
activation of
PI3kinase and JNK activation