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HRAS — TGFB1

Text-mined interactions from Literome

Akhurst et al., J Pathol 1999 (Cell Transformation, Neoplastic...) : This spindle cell transformation can also be induced in vitro or in vivo by TGF beta 1 , possible by synergizing with mutant H-ras
Hudes et al., Clin Cancer Res 2000 (Neoplasms) : Putative mechanisms of action include activation of the transforming growth factor beta pathway and/or inhibition of p21ras signaling, leading to differentiation or apoptosis
Blanchette et al., J Biol Chem 2001 : Using HepG2 cells transfected with fur P1 LUC ( luciferase ) promoter construct, we observed that forced expression of a dominant negative mutant form of the small G protein p21(ras) ( RasN17 ) inhibited TGF beta 1-induced fur gene transcription, suggesting the involvement of the p42/p44 MAPK cascade
Mulder et al., J Biol Chem 1992 : Activation of p21ras by transforming growth factor beta in epithelial cells ... Further, the CCL64 epithelial cell line, extremely sensitive to growth inhibition by TGF beta, displayed a concentration dependent increase in GTP bound to p21ras by TGF beta 1 and a rapid activation of p21ras by TGF beta 2
Cosgaya et al., Oncogene 1996 : A functional p21ras is required for the regulation of TGF-beta1 by ligands of tyrosine kinase receptors since expression of oncogenic ras in PC12 cells also increases TGF-beta1 transcripts, and a dominant inhibitory ras mutant blocks activation of TGF-beta1 gene expression by NGF