Bode et al., J Immunol 2001
:
The inhibitory effect of IL-1 beta on IL-6 induced alpha 2-macroglobulin expression is due to activation of NF-kappa B ... The observation that inhibition of IL-6 induced transcriptional activation of this promoter by IL-1beta is reversed by cotransfection with I-kappaBalpha provides evidence that NF-kappaB activation by IL-1beta is responsible for inhibition of IL-6 mediated trans activation of the alpha(2)-macroglobulin gene
Misra et al., J Biol Chem 2006
(Prostatic Neoplasms) :
The effects of alpha2M* on the NF-kappaB activation, antiapoptotic signaling, unfolded protein response signaling, and proapoptotic signaling were also reversed by this treatment
Misra et al., Biochem Biophys Res Commun 2010
(Prostatic Neoplasms) :
Here we report that treatment of prostate cancer cells with antibody directed against the carboxyl terminal domain of GRP78 inhibits alpha2M* induced activation of NF-kappaB2 by approximately 50 % while exerting a lesser effect of approximately 20 % on NF-kappaB1 activation