◀ Back to IL4
CXCR4 — IL4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Jinquan et al., Immunology 2000
(Inflammation) :
The
regulation of
CXCR4 expression in CD4+ T lymphocytes by
IL-4 and IL-10 could be blocked by a selective inhibitor of protein kinase ( staurosporine ) or by a selective inhibitor of cAMP- and cGMP dependent protein kinase ( H-8 ), indicating that these cytokines regulate CXCR4 on CD4+ T lymphocytes via both cAMP and cGMP signalling pathways
Nagase et al., Int Arch Allergy Immunol 2001
(Hypersensitivity) :
CXCR4 expression was completely
attenuated by
IL-4 and IL-5 and upregulated by IFN-gamma and dexamethasone, while CCR3 expression was only marginally affected
Iikura et al., J Leukoc Biol 2001
:
IL-5, GM-CSF, and
IL-4 also
down-regulated CXCR4 expression
Pedroza-Martins et al., J Virol 2002
(HIV Infections) :
IL-2 and
IL-4 together
increased expression of
CXCR4 and CCR5 in this population, whereas IL-4 and IL-7 increased CXCR4 but not CCR5 expression
Vicenzi et al., J Leukoc Biol 2002
:
Interferon-gamma (IFN-gamma) down-regulated CCR5 in Th1 cells and inhibited, whereas
interleukin-4 (IL-4) up-regulated
CXCR4 and enhanced the spreading of R5 and R5X4 viruses in polarized CB lines
Princen et al., AIDS Res Hum Retroviruses 2003
:
It has been proven that the
CXCR4 expression level in T cells is strongly
up-regulated by
interleukin (IL)-4 , a Th2-type cytokine that is secreted preferentially in HIV infected patients in a later stage of disease
Creery et al., Viral Immunol 2006
:
Differential
regulation of
CXCR4 and CCR5 expression by
interleukin (IL)-4 and IL-13 is associated with inhibition of chemotaxis and human immunodeficiency Virus ( HIV ) type 1 replication but not HIV entry into human monocytes ... In this study, we investigated the
effects of
IL-4 and IL-13 on the expression of
CXCR4 and CCR5, and the biological implications of alteration of CXCR4 and CCR5 regulation on monocytic cells with respect to their migration in response to chemokines, HIV entry, and its replication
Okuma et al., J Infect Dis 2008
(Disease Models, Animal...) :
Experiments reported here show that ( 1 ) synthesis of human
IL-4 in vivo
augmented CXCR4 expression on human CD4 ( + ) lymphocytes and importantly led to productive infection of not only X4 HIV-1 ( NL4-3 ) but also multidrug-resistant primary clinical isolates and that ( 2 ) the in vivo infection could be significantly blocked by the administration of a CXCR4 antagonist
Wilson et al., Infect Immun 1995
(Leishmaniasis, Visceral) :
Recombinant
Lcr1 , cloned adjacent to polyhistidine and purified on a nickel affinity column,
stimulated gamma interferon but not
interleukin-4 (IL-4) , IL-5, or IL-10 secretion by T-cell enriched splenocytes from either susceptible or resistant mice during L. chagasi infection
Jourdan et al., J Immunol 1998
:
IL-4 induces functional cell-surface expression of
CXCR4 on human T cells ... Here we report that
IL-4 specifically
enhances cell surface expression of
CXCR4 on resting peripheral and cord blood T cells ... The
IL-4 induced
CXCR4 is functional since interaction with its ligand, stromal derived factor (SDF)-1, activates the p42 MAP-kinase ERK-2
Zoeteweij et al., J Immunol 1998
(HIV Infections) :
Expression of cell surface
CXCR4 on cLC was
up-regulated by
IL-4 and TGF-beta1 and inhibited by IFN-alpha, IFN-beta, and IFN-gamma, whereas cytokines did not appreciably regulate CCR5
Wang et al., J Leukoc Biol 1998
:
Among a panel of cytokines and stimulants, a Th2 type cytokine
interleukin-4 (IL-4) selectively
up-regulated the mRNA level as well as surface protein expression of
CXCR4 within 16 h