Gene interactions and pathways from curated databases and text-mining

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IL4 — TIMP2

Text-mined interactions from Literome

Ihn et al., J Immunol 2002 (MAP Kinase Signaling System) : IL-4 induction of TIMP-2 expression was dependent upon transcription ... The p38 mitogen activated protein kinase ( MAPK ) inhibitors SB202190 and SB203580 suppressed IL-4 induced TIMP-2 expression, suggesting the involvement of p38 MAP kinase in the signaling of IL-4 leading to TIMP-2 expression ... The expression of the dominant negative mutant p38 MAPK represses the IL-4 induced TIMP-2 expression in human dermal fibroblasts
Shin et al., Rheumatology (Oxford) 2003 (Arthritis, Experimental...) : In the serum of PG201 treated mice, the level of TIMP-2 and the ratio of TIMP-2 to MMP-2 were significantly elevated, and the level of IL-4 , but not of IL-10, was increased
Bergeron et al., Clin Exp Allergy 2003 (Asthma) : The effect of IL-4 on metalloproteinase-2 ( MMP-2 ) and tissue inhibitor of metalloproteinase-2 ( TIMP-2 ) production and gene expression was evaluated