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FOXO1 — TNF
Text-mined interactions from Literome
Alikhani et al., J Biol Chem 2005
:
These results indicate that
TNF induces activation of the
FOXO1 transcription factor, which acts as a master switch to control apoptosis
Abid et al., J Biol Chem 2005
(Hyperplasia) :
PDGF-BB,
tumor necrosis factor-alpha , and insulin-like growth factor 1 treatment
resulted in the nuclear exclusion of
FoxO , whereas PDGF-BB alone down-regulated the FoxO target gene, p27 ( kip1 ), and enhanced cell survival and progression through the cell cycle
Ludikhuize et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid...) :
Immunoblotting was used to assess the interleukin-1beta (IL-1beta)- and
tumor necrosis factor alpha (TNFalpha) induced phosphorylation of
FoxO1 and FoxO4 in cultured fibroblast-like synoviocytes ( FLS ) and macrophages
Moylan et al., Am J Physiol Cell Physiol 2008
:
We used TNF treated C2C12 myotubes to test the hypothesis that
AKT-Foxo1/3 signaling
mediates TNF regulation of atrogin mRNA
Sheriff et al., Mol Cell Endocrinol 2012
(Burns...) :
DAG also reversed or attenuated the
TNF+IFN induced reduction in phosphorylation of Akt,
FOXO1 , 4E-BP-1, and GSK-3ß in myotubes ... DAG also reversed or attenuated the
TNF+IFN induced reduction in phosphorylation of Akt,
FOXO1 , 4E-BP-1, and GSK-3ß in myotubes
Abdul-Aziz et al., Diabetes Metab Syndr 2012
(Diabetes Mellitus, Experimental...) :
Since,
TNF-a is
involved in activation of transcription factor
FOXO1 along with oxidative stress mediated by neutrophils