Gene interactions and pathways from curated databases and text-mining

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FOXO1 — TNF

Text-mined interactions from Literome

Alikhani et al., J Biol Chem 2005 : These results indicate that TNF induces activation of the FOXO1 transcription factor, which acts as a master switch to control apoptosis
Abid et al., J Biol Chem 2005 (Hyperplasia) : PDGF-BB, tumor necrosis factor-alpha , and insulin-like growth factor 1 treatment resulted in the nuclear exclusion of FoxO , whereas PDGF-BB alone down-regulated the FoxO target gene, p27 ( kip1 ), and enhanced cell survival and progression through the cell cycle
Ludikhuize et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid...) : Immunoblotting was used to assess the interleukin-1beta (IL-1beta)- and tumor necrosis factor alpha (TNFalpha) induced phosphorylation of FoxO1 and FoxO4 in cultured fibroblast-like synoviocytes ( FLS ) and macrophages
Moylan et al., Am J Physiol Cell Physiol 2008 : We used TNF treated C2C12 myotubes to test the hypothesis that AKT-Foxo1/3 signaling mediates TNF regulation of atrogin mRNA
Sheriff et al., Mol Cell Endocrinol 2012 (Burns...) : DAG also reversed or attenuated the TNF+IFN induced reduction in phosphorylation of Akt, FOXO1 , 4E-BP-1, and GSK-3ß in myotubes ... DAG also reversed or attenuated the TNF+IFN induced reduction in phosphorylation of Akt, FOXO1 , 4E-BP-1, and GSK-3ß in myotubes
Abdul-Aziz et al., Diabetes Metab Syndr 2012 (Diabetes Mellitus, Experimental...) : Since, TNF-a is involved in activation of transcription factor FOXO1 along with oxidative stress mediated by neutrophils