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KDR — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of KDR-PTPN11 → TNF (increases)
  Evidence: TNF- inhibits VEGF signaling by recruiting SHP-2 to the VEGFR2 in ECs (42).

Text-mined interactions from Literome

Zhang et al., J Biol Chem 2003 : In response to TNF , Etk and VEGFR2 form a complex resulting in a reciprocal activation between the two kinases
Sugano et al., Circulation 2004 (Ischemia) : In a rat model of hindlimb ischemia, VEGF increased but activation of KDR/flk-1 was suppressed , possibly by TNF-alpha , which might impair angiogenesis
Yang et al., J Surg Res 2004 : TNF-alpha significantly reduced protein levels of VEGFR-2 , VEGFR-3, and NRP-1 by 59, 35, and 22 %, respectively
Zhao et al., Br J Ophthalmol 2007 (Diabetic Retinopathy) : TNFalpha up regulated both VEGF-C and vascular endothelial growth factor receptor-2 ( VEGFR)-2 expression in endothelial cells in a dose dependent manner, but had no effect on VEGFR-3
Galvão et al., Biol Reprod 2012 : In early CL cells, TNF increased angiogenic activity ( bovine aortic endothelial cell viability ) and VEGF and VEGFR2 mRNA levels and decreased CD36 ( real-time PCR relative quantification )
Chan et al., Arterioscler Thromb Vasc Biol 2012 (Diabetes Mellitus...) : In mice with diabetes mellitus, excessive tumor necrosis factor-a induced miR-200b blunting proangiogenic functions of GATA2 and VEGFR2