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PTX3 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PTX3 → TNF (increases)
  Evidence: On the other hand, PTX3, synthesized locally by endothelial cells in response to IL-1b and TNF-a, binds FGF2 and acts as a natural angiogenesis inhibitor (see above), thus allowing a fine tuning of FGF2 pro-angiogenic activity in inflammation.

Text-mined interactions from Literome

Combaret et al., Mol Biol Rep 1999 (Cachexia...) : Pentoxifylline ( PTX ) is a very inexpensive xanthine derivative, which is widely used in humans as a haemorheological agent, and inhibits tumor necrosis factor transcription
Poulakis et al., Respir Med 1999 (Lung Diseases) : The aim of this study was to investigate the effects of pentoxifylline ( PTX ) on the production of TNF-alpha , IL-1 beta, IL-6 and GM-CSF by lipopolysaccharide (LPS) stimulated alveolar macrophages ( AM ) ... The TNF-alpha production by AM was significantly suppressed in the presence of PTX at concentrations of 2.0 and 1.0 mM, while production of IL-1 beta, IL-6 and GM-CSF remained unaffected ... In PBM cultures, PTX significantly suppressed the production of TNF-alpha and GM-CSF, at all tested concentrations ... The present study provides evidence that PTX selectively suppresses the production of TNF-alpha by LPS stimulated AM and may have a role in the treatment of lung diseases where TNF-alpha is involved
Luchetti et al., Clin Exp Immunol 2000 (Arthritis, Rheumatoid...) : Unlike the classical pentraxins, the long pentraxin PTX3 is expressed in response to IL-1beta and tumour necrosis factor-alpha (TNF-alpha) , but not to IL-6, in various cell types
Goodman et al., J Leukoc Biol 2000 : TNF and interleukin-1 (IL-1) potently induced TSG-14 expression in 3T3 fibroblasts but not in peritoneal macrophages
Marcinkiewicz et al., Immunopharmacology 2000 : We have found that PTX , at concentrations below 100 microg/ml, selectively inhibited the production of TNF-alpha ... However, at higher concentrations, PTX inhibited the production of TNF-alpha , IL-10, and IL-12 p35, but surprisingly, PTX enhanced the production of IL-12 p40
Porter et al., Am J Physiol Regul Integr Comp Physiol 2000 (Anorexia...) : To improve our understanding of the role that these two cytokines serve in mediating infection during anorexia, we investigated the ability of pentoxifylline ( PTX ) , a potent inhibitor of TNF-alpha production, to block the anorectic effects of the bacterial products lipopolysaccharide (LPS) and muramyl dipeptide ( MDP ) in rats
Akriviadis et al., Gastroenterology 2000 (Acute Disease...) : An earlier pilot study from our liver unit suggested benefit from treatment with pentoxifylline ( PTX ) , an inhibitor of tumor necrosis factor (TNF) , in severe acute alcoholic hepatitis
Hoebe et al., Biochem Pharmacol 2001 : PTX completely inhibited LPS induced TNF-alpha production and attenuated IL-6 only after 48 hr of incubation
Kim et al., Ren Fail 2001 (Acute Kidney Injury...) : This study was undertaken to determine whether pentoxifylline ( PTX ) , an inhibitor of TNF-alpha production, provides a protective effect against ischemic acute renal failure in rabbits
Park et al., Int J Lepr Other Mycobact Dis 2001 : PTX inhibited production of NO ( IC50 approximately equal to 1.0 mg/ml ) and TNF-alpha ( IC50 approximately equal to 0.05 mg/ml ) in a dose dependent fashion
Takehana et al., Circ J 2002 (Autoimmune Diseases...) : PTX in vitro could suppress T cell proliferation and inhibit TNF-alpha and interferon-gamma production
Costelli et al., Cytokine 2002 (Body Weight...) : In order to verify whether a combined anticytokine treatment may synergistically counteract muscle protein degradation, tumour bearing rats were treated with pentoxyfilline ( PTX , an inhibitor of TNF-alpha synthesis ), or with suramin ( SUR, an antiprotozoal drug blocking the peripheral action of several cytokines including IL-6 and TNF-alpha ), or both the drugs, and the effects on muscle proteolytic systems were assessed
Hou et al., J Immunol 2003 (MAP Kinase Signaling System...) : PTX-DC had also increased allostimulatory capacity and IL-12 and TNF-alpha production
Schandené et al., Immunology 1992 : In this study, we found that PTX differentially regulates the production of TNF-alpha and interleukin-6 (IL-6) ... Indeed, PTX at high concentrations triggers the production of IL-6 but not of TNF-alpha by peripheral blood mononuclear cells ( PBMC ) ... In this system, PTX was found to inhibit the secretion of both TNF-alpha and IL-6 by T cells ... We suggest that cAMP could be involved in these differential effects of PTX on production of TNF-alpha and of IL-6
Lima et al., J Periodontol 2004 (Alveolar Bone Loss...) : Pentoxifylline ( PTX ) and thalidomide ( TLD ) have been shown to inhibit cytokine synthesis, mainly tumor necrosis factor (TNF)-alpha , in different inflammatory conditions
Lin et al., J Microbiol Immunol Infect 2004 : While indo and ibu treatment resulted in increased TNF production, PTX , VZ 65, and AA-861 significantly inhibited TNF production, whether administered simultaneously with LPS or 30 min after LPS treatment ... We conclude that while PTX reduced TNF protein levels by inhibiting TNF mRNA transcription, both VZ 65 and AA-861 exerted opposing effects on TNF transcription and increased mRNA stability
Banfi et al., J Pharmacol Exp Ther 2004 (Brain Ischemia...) : PTX treatment did induce a greater increase of serum tumor necrosis factor-alpha (TNF-alpha) , but not of interleukin (IL)-1beta and IL-6 induced by in vivo administration of lipopolysaccharide (LPS), which suggests a protective role for TNF-alpha
Kwiecień et al., J Physiol Pharmacol 2004 (Disease Models, Animal...) : Therefore, the aim of our present study was to determine the action of pentoxyfilline ( PTX ) , an inhibitor of tumor necrosis factor alpha (TNFalpha) with or without NOS inhibition by L-NNA administration in rats with water immersion and restraint stress ( WRS ) -induced gastric lesions
Luchetti et al., Clin Exp Rheumatol 2004 (Scleroderma, Systemic) : Unlike the classical pentraxins, PTX3 is expressed in response to IL-1beta and TNF-alpha but not to IL-6 ... Unlike the classical pentraxins, PTX3 is expressed in response to IL-1beta and TNF-alpha but not to IL-6
Koppe et al., J Hepatol 2004 (Choline Deficiency...) : Pentoxifylline ( PTX ) attenuates TNF-alpha production, acts as an antioxidant and decreases mortality in alcoholic steatohepatitis
Coimbra et al., J Trauma 2004 (Sepsis) : These results suggest that PTX-inhibition of oxidative burst occurs distal to PKC and may be either due to direct inhibition of NADPH oxidase or inhibition of MAPK phosphorylation, leading to decreased adhesion molecule expression and TNF-alpha synthesis
Ji et al., Ann Clin Lab Sci 2004 (Disease Models, Animal...) : At all dosages, PTX reduced the activation of NF-kappaB and the production of TNF-alpha and IL-6, but enhanced the release of IL-10 ... In conclusion, PTX suppressed the production of proinflammatory cytokines such as TNF-alpha and IL-6 in rat intestine, and enhanced the endotoxin induced production of IL-10
Nauta et al., Kidney Int 2005 : Further analysis showed that interleukin (IL)-1 and tumor necrosis factor-alpha (TNF-alpha) stimulation strongly enhanced the expression and production of PTX3 in PTECs in a dose- and time dependent manner
Han et al., J Immunol 2005 : TNFalpha induced long pentraxin PTX3 expression in human lung epithelial cells via JNK ... TNFalpha induced long pentraxin PTX3 expression in human lung epithelial cells via JNK ... Using human lung cell lines and primary epithelial cells, we found that PTX3 expression was significantly up-regulated by TNF-alpha in a time- and dose dependent manner, but not by LPS ... Pretreatment with either actinomycin D or cycloheximide abolished TNF-alpha induced PTX3 expression, indicating the requirement for both transcriptional and translational regulation ... The TNF-alpha induced PTX3 expression was blocked by SP600125, a JNK-specific inhibitor, but not by the inhibitors against NF-kappaB, ERKs, or p38 MAPK
Dragovic et al., Biol Reprod 2007 : Using real-time RT-PCR, SB-431542 also attenuated GDF9-, activin A-, and oocyte induced OOX expression of hyaluronan synthase 2, tumor necrosis factor alpha induced protein 6, prostaglandin synthase 2, and pentraxin 3
Zhang et al., J Immunother 2007 : PTX significantly reduced the production of TNF-alpha and IFN-gamma in mature DCs ( mDCs )
El-Ghoneimi et al., Transplant Proc 2007 (Reperfusion Injury) : In conclusion, PTX inhibits liver TNFalpha gene transcription, decreases serum TNFalpha levels, and reduces liver injury following normothermic I-R
de Moura et al., Toxicology 2008 (Kidney Diseases...) : PTX associated with meglumine antimonate ( Sb ( V ) ) reduced TNF-alpha serum levels and was effective in preventing renal functional alterations
Alegre et al., Transplantation 1991 : In vitro experiments on human peripheral blood leukocytes indicated that PTX alone or in synergy with methylprednisolone ( m-PDS ) also inhibited the release of TNF and IL-2 induced by OKT3
Andrade et al., Mem Inst Oswaldo Cruz 2008 (Acute Disease...) : In the present study, pentoxifylline ( PTX ) , an inhibitor of TNF-alpha was investigated on its action upon splenic necrosis, parasitemia and host survival
Shaw et al., Eur J Heart Fail 2009 (Chronic Disease...) : Conversely, a possible exception is pentoxifylline ( PTX ) , a putative TNF-alpha inhibitor with possible ( but ill defined ) vasodilatory properties
Groesdonk et al., Kidney Blood Press Res 2009 (Acute Kidney Injury...) : Renal TNF-alpha release was significantly reduced by URO 20 microg/l ( from 178 +/- 23 to 45.2 +/- 2 and 47 +/- 3 pg/ml ) in the E. coli + URO 20 microg/l and by PTX in the E. coli + PTX group if added to the perfusion medium upon start of perfusion
Taha et al., J Physiol Pharmacol 2009 (Endotoxemia) : As expected, PTX reduced also production of TNF ... PTX to a similar extent increased influx of leukocyte into peritoneal cavity, decreased production of TNF and reduced expression of VCAM-1 in vascular intima ... PTX inhibits production of TNF and may decrease inflammatory reaction both in vitro and in vivo, but these effects are independent of HO-1
Han et al., Intensive Care Med 2011 (Acute Lung Injury...) : PTX3 deficiency also enhanced LPS induced tissue factor expression/activation in the lung and increased tumor necrosis factor-alpha and monocyte chemoattractant protein-1 levels in the plasma
Lucetti et al., Journal of inflammation (London, England) 2010 : In this model, the effect of a very low dose of LA ( 0.1 mg/kg ) was potentiated by the same dose of pentoxifylline ( PTX ) , a known TNF-alpha inhibitor ... Furthermore, the LA effect was potentiated by PTX ( a TNF-alpha inhibitor )
Satomura et al., Mod Rheumatol 2013 (Arthritis, Rheumatoid...) : Neither soluble TNF receptor ( etanercept ) nor recombinant IL-1 receptor antagonist affected PTX3 production by SAA stimulated synoviocytes, suggesting that SAA directly induces PTX3
Woo et al., Molecular vision 2013 (MAP Kinase Signaling System) : In this study, production of PTX3 was induced by IL-1ß and TNF-a dose- and time-dependently, but not by IFN-? in ARPE-19 cells ... Furthermore, pretreatment with extracellular signal regulated kinase1/2 and nuclear factor kappa-light-chain-enhancer of activated B cells specific inhibitor abolished IL-1ß and TNF-a induced PTX3 production, but the other inhibitors had no effect
Skelly et al., PloS one 2013 : Differences between IL-1ß and TNF-a induced hippocampal profiles, specifically for IL-6 and CXCL1 prompted a temporal analysis of systemic and central responses at 1, 2, 4, 8 and 24 hours, which revealed that IL-1ß and TNF-a both induced the chemokines CXCL1 and CCL2 but only IL-1ß induced the pentraxin PTX3
Rieneck et al., Immunol Lett 1993 : The expression of tumour necrosis factor (TNF)alpha , TNF beta interleukin (IL)-2 and interferon (IFN)gamma was inhibited by PTX in a dose dependent manner, whereas expression of IL-1 alpha, IL-1 beta, and IL-6 was unaffected at concentrations up to 300 microM of PTX
Bruynzeel et al., J Invest Dermatol 1995 : PTX can suppress tumor necrosis factor-alpha production and function, and inhibits leukocyte-endothelial cell adherence ... In keratinocyte monolayers the interferon-gamma or tumor necrosis factor-alpha induced intercellular adhesion molecule-1 expression could not be inhibited by PTX
Elbim et al., Eur Cytokine Netw 1995 : In addition to the PTX induced decrease of TNF production, these effects on PMN could be beneficial in pathological conditions where high TNF production may induce excessive PMN activation, leading to vascular damage and tissue injury
Lee et al., J Immunol 1993 : Nuclear run-on analysis indicated that TNF induces the expression of the TSG-14 gene at the transcriptional level, and that de novo protein synthesis is not required for induction of TSG-14 mRNA
Lundblad et al., Shock 1995 (Cecal Diseases...) : The primary effect of PTX in this sequence is probably reduction of TNF
Neuner et al., Immunology 1994 : Due to the therapeutic implications, the present study addressed the in vivo effects of PTX on the release of TNF-alpha , IL-1 beta, IL-6 and IL-8 by human peripheral blood mononuclear cells ( PBMC )
Alles et al., Blood 1994 : Tumor necrosis factor-alpha (TNF-alpha) was a less-effective inducer of PTX3 , whereas IL-6, monocyte chemotactic protein-1, macrophage colony stimulating factor, granulocyte-macrophage colony stimulating factor, and interferon-gamma were inactive
DeVault et al., Transplantation 1994 : The hemorrheologic agent pentoxifylline ( PTX ) inhibits the synthesis of TNF alpha in vitro in response to a variety of stimuli, including OKT3
Jewett et al., J Clin Immunol 1994 : Because pentoxifylline ( PTX ) inhibits TNF-alpha synthesis and secretion in monocytes, we hypothesized that PTX may also inhibit TNF-alpha secretion by NK cells and thus would inhibit IL-2 mediated activation of free cells ... IL-2 mediated secretion of TNF-alpha by the free cells was inhibited by PTX ... Also, PTX inhibited IL-2 triggered upregulation of the expression of CD69, CD25, ICAM-1, and p75TNF-R on the cell surface ... These findings demonstrate that PTX has a marked suppression on IL-2 mediated activation of immature free NK cells and that the suppression is due, in large part, to PTX mediated inhibition of endogenous TNF-alpha secretion
Mizutani et al., J Urol 1994 (Carcinoma, Renal Cell...) : Pentoxifylline ( PTX ) suppressed TNF-alpha gene transcription and downregulates the expression of TNF-alpha mRNA and the secretion of TNF-alpha protein in macrophages and monocytes
Mándi et al., Res Exp Med (Berl) 1995 (Sepsis) : When peripheral white blood cells were stimulated with either E. coli lipopolysaccharide (LPS) or Staphylococcus aureus, pentoxifiline ( PTX ) inhibited TNF production ... PTX inhibited not only the TNF production of monocytes, but also the TNF secretion of both granulocytes and unseparated whole blood
Cui et al., Chin Med J (Engl) 1995 (Pneumococcal Infections...) : Pentoxifylline ( PTX ) , a phosphodiesterase inhibitor, significantly attenuated TNF alpha release caused either by Streptococcus pneumoniae or by its lysates ... It was found that PTX significantly attenuated TNF alpha activity in serum and bronchoalveolar lavage fluid, and inhibited white blood cell chemotaxis, emigration and infiltration
Bernard et al., J Cardiovasc Pharmacol 1995 : Because inflammatory processes involve both leukocytes and vascular cells, we tested the effects of PTX on TNF and interleukin-6 (IL-6) production by the vessel wall in response to lipopolysaccharide (LPS)
Navarro et al., AIDS 1996 : Moreover, PTX reduced TNF-alpha , IFN-gamma and IL-10 production and NF-kappa B activation
Okuda et al., Immunopharmacology 1996 (Encephalomyelitis, Autoimmune, Experimental) : Semiquantitative reverse transcriptase-polymerase chain reaction analysis revealed that PTX at this dose reduced the mRNA levels for tumor necrosis factor (TNF)-alpha , interleukin (IL)-1 beta and IL-6 in peripheral blood mononuclear cells ( PBMC ) of mice with EAE
Tsujino et al., J Neuroimmunol 1997 (Paraparesis, Tropical Spastic) : To clarify if pentoxifylline ( PTX ) may have therapeutic potential for human T-cell lymphotropic virus type I ( HTLV-I ) -associated myelopathy ( HAM ), we investigated the in vitro effect of PTX on spontaneous proliferation of peripheral blood lymphocytes ( SPP ), as well as on the expression of adhesion molecules, such as lymphocyte function antigen-1 ( LFA-1 ) and very late activation antigen-4 (VLA-4), and the production of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) , interferon-gamma (IFN-gamma) and granulocyte-monocyte colony stimulating factor ( GM-CSF ), in cultured PBMC from 10 HAM patients, compared with control subjects ... PTX caused a significant suppression of spontaneous production of TNF-alpha by cultured PBMC of HAM patients
Bruynzeel et al., Arch Dermatol Res 1997 : Previous studies have demonstrated that PTX can suppress TNF alpha production and function, and can inhibit the adhesion of neutrophils and monocytes to endothelial cells
Dong et al., J Clin Immunol 1997 : PTX at a 3.5 x 10 ( -5 ) M concentration significantly inhibited T cell proliferation and the production of tumor necrosis factor-alpha , interleukin-2, and interleukin-4
D'Hellencourt et al., Int J Immunopharmacol 1996 : We investigated PTX effects on production and mRNA expression of TNF alpha , IL-1 beta, IL-6, IL-8, TNF beta and IL-10 ... Our results showed that expression and production of TNF alpha and TNF beta were inhibited by PTX in a dose dependent manner
Reimund et al., Gut 1997 (Colitis, Ulcerative...) : PTX inhibited the release of TNF-alpha by PBMCs from patients with inflammatory bowel disease and the secretion of TNF-alpha and IL-1 beta by organ cultures of inflamed mucosa from the same patients
Sampaio et al., Clin Exp Immunol 1998 (Erythema Nodosum...) : The effect of PTX on TNF-alpha production was examined in leprosy patients at the protein level and at the transcriptional level as well ... These data suggest that PTX inhibits TNF-alpha production in ENL patients both in vivo and in vitro, and it may be useful in the treatment of leprosy patients undergoing ENL
Polentarutti et al., Eur J Immunol 1998 : PTX3 is a prototypic long pentraxin expressed by various cell types, most prominently monocytes and endothelial cells, in response to interleukin-1 (IL-1), tumor necrosis factor (TNF) and bacterial products
Weber et al., Ann Neurol 1998 (Multiple Sclerosis) : In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive effect of IFN-beta1b and the phosphodiesterase inhibitor pentoxifylline ( PTX ) on proliferation and the production of tumor necrosis factor-alpha (TNF-alpha) , lymphotoxin ( LT ), and interferon-gamma (IFN-gamma)
Schratzberger et al., Immunopharmacology 1999 : In the present study, we investigated the effects of the anti-inflammatory drug pentoxifylline ( PTX ) on activation of endothelial cells for enhanced adhesion and transmigration of neutrophils by lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF) , interleukin-1 (IL-1) and granulocyte colony stimulating factor ( G-CSF ) ... Upon stimulation with TNF or LPS, HUVEC produced IL-8 and PTX affected this process in opposing fashions, with inhibition of the effects of TNF and augmentation of those of LPS