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JUN — MAP3K3

Text-mined interactions from Literome

Che et al., Circ Res 2002 : Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells : role of Gab1 and MEKK3 in TNF-alpha induced c-Jun and NF-kappaB activation and adhesion molecule expression ... Interestingly, Gab1 inhibited c-Jun transcriptional activity induced by MEKK3 but not MEKK1 and MEK4 ... Gab1 associated with MEKK3, and a catalytically inactive form of MEKK3 inhibited TNF-alpha induced c-Jun and NF-kappaB transcriptional activation, suggesting a critical role for Gab1 and MEKK3 in TNF-alpha signaling
Lerner-Marmarosh et al., Arterioscler Thromb Vasc Biol 2003 (Inflammation) : Because MEKK3 and Gab1 are critical for TNF-alpha induced c-Jun and NF-kappaB activation, we determined the role of SHP-2 phosphatase activity in MEKK3 signaling ... A catalytically inactive form of SHP-2 increased MEKK3/Gab1 interaction and inhibited MEKK3 ( but not MEKK1 ) -mediated c-Jun and NF-kappaB activation
Xu et al., J Biol Chem 2004 : TRAF7 potentiates MEKK3 induced AP1 and CHOP activation and induces apoptosis
Lim et al., American journal of translational research 2009 : Ras-Raf1-ERK1/2 dependent AP-1 activation positively regulates MUC5AC mucin induction by S. pneumoniae, whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it
Jin et al., Dev Biol 2013 : Second, MAP3K1 potentiated AP-2a expression and SRF and AP-1 activity, but its target genes were enriched for binding motifs of AP-2a and SRF, and not AP-1, suggesting the existence of novel MAP3K1-AP-2a/SRF modules in gene regulation