Gene interactions and pathways from curated databases and text-mining

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EPHB2 — PCNA

Text-mined interactions from Literome

Keenan et al., J Biol Chem 2001 : Here, we show that ERK also affects CDK2-cyclin E activation by regulating the subcellular localization of CDK2
Sanz-González et al., Biochem Biophys Res Commun 2004 : Role of E2F and ERK1/2 in STI571 mediated smooth muscle cell growth arrest and cyclin A transcriptional repression
Ingram et al., Kidney Int 2004 (MAP Kinase Signaling System) : Hcy- induced increases in thymidine incorporation and PCNA expression at 24 hours were Erk dependent
Yu et al., Frontiers in bioscience : a journal and virtual library 2005 : Role of ERK1/2 in FSH induced PCNA expression and steroidogenesis in granulosa cells
Merkerova et al., Leuk Res 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : PCNA inhibition led to down-regulation of CDK1, CDK4, PLK1, ERK3 , JNK1, STAT5, and several inhibitors of apoptosis ( DAXX, Mdm2, survivin )
Bokemeyer et al., Nephrol Dial Transplant 2007 (Glomerulonephritis) : In stimulated MC, inhibition of ERK reduced cyclin dependent kinase 2 (CDK2) phosphorylation, CDK2 activity and cyclin E/A expression, whereas downregulation of CDK inhibitor p27 ( Kip1 ) expression was inhibited
Neary et al., Purinergic Signal 2005 : Because FGF2 and P2 purinergic receptors are coupled to extracellular signal regulated protein kinase ( ERK ), a key member of a signaling cascade that regulates proliferation, we also investigated the role of ERK in regulating cyclin expression induced by FGF2 and ATP
Ugland et al., Mol Biol Cell 2008 : Concomitant with this growth inhibition, however, cyclin E levels are increased in a MEK/ERK dependent manner
Zhu et al., Stroke 2009 (Intracranial Arteriovenous Malformations...) : Immunostaining and Western blot revealed a more significant PTEN downregulation in PTEN methylated CCMs in comparison to PTEN unmethylated CCMs. Reduced PTEN expression was inversely correlated to the expression of proliferating cell nuclear antigen and to the activation of Erk1,2 , but not of Akt
Frost et al., Mol Cancer Ther 2009 (Multiple Myeloma...) : However, only an ERK inhibitor prevented D-cyclin IRES activity in resistant `` low-AKT '' myeloma cells
Wang et al., Neurosci Lett 2009 : Cell-cycle regulators such as cyclin dependent kinase 2 (Cdk2) , Cyclin D1 and Hes1 mediated the effect of Erk on NSCs proliferation and differentiation
Song et al., Biochim Biophys Acta 2010 (MAP Kinase Signaling System) : We further show that IKKalpha dependent downregulation of Cyclin D1 expression in the UVB response results from the reduction of ERK1/2 dependent Cyclin D1 transcription coupled with an increase of p38 kinase dependent Cyclin D1 proteolysis
Siejka et al., Prostate 2010 (Prostatic Hyperplasia) : We also measured by Western blot the influence of GHRH and GHRH antagonist JMR-132 on the expression of the PCNA and the activation of ERK1/2 and JAK/STAT3
Groehler et al., J Cell Biol 2010 (Genomic Instability) : We now show that ERK8 ( extracellular signal regulated kinase 8 ) is required for PCNA protein stability
Li et al., J Basic Microbiol 2013 : The ERK1/2-specific inhibitor significantly blocked the increased expression in Egr-1 and PCNA induced by coccoid H. pylori
Sensui et al., Dev Biol 2012 (Calcium Signaling...) : GST-dN85-cyclin , which maintains Cdk1 activity, caused ERK activity in the eggs to persist for over 120 min after fertilization, and prolonged [ Ca ( 2+ ) ] ( i ) oscillations