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EPHB2 — PCNA
Text-mined interactions from Literome
Keenan et al., J Biol Chem 2001
:
Here, we show that
ERK also
affects CDK2-cyclin E activation by regulating the subcellular localization of CDK2
Sanz-González et al., Biochem Biophys Res Commun 2004
:
Role of E2F and
ERK1/2 in STI571 mediated smooth muscle cell growth arrest and
cyclin A transcriptional repression
Ingram et al., Kidney Int 2004
(MAP Kinase Signaling System) :
Hcy- induced increases in thymidine incorporation and
PCNA expression at 24 hours were
Erk dependent
Yu et al., Frontiers in bioscience : a journal and virtual library 2005
:
Role of
ERK1/2 in FSH
induced PCNA expression and steroidogenesis in granulosa cells
Merkerova et al., Leuk Res 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
PCNA inhibition
led to down-regulation of CDK1, CDK4, PLK1,
ERK3 , JNK1, STAT5, and several inhibitors of apoptosis ( DAXX, Mdm2, survivin )
Bokemeyer et al., Nephrol Dial Transplant 2007
(Glomerulonephritis) :
In stimulated MC, inhibition of
ERK reduced cyclin dependent kinase 2 (CDK2) phosphorylation, CDK2 activity and
cyclin E/A expression, whereas downregulation of CDK inhibitor p27 ( Kip1 ) expression was inhibited
Neary et al., Purinergic Signal 2005
:
Because FGF2 and P2 purinergic receptors are coupled to extracellular signal regulated protein kinase ( ERK ), a key member of a signaling cascade that regulates proliferation, we also investigated the
role of
ERK in regulating
cyclin expression induced by FGF2 and ATP
Ugland et al., Mol Biol Cell 2008
:
Concomitant with this growth inhibition, however,
cyclin E levels are increased in a
MEK/ERK dependent manner
Zhu et al., Stroke 2009
(Intracranial Arteriovenous Malformations...) :
Immunostaining and Western blot revealed a more significant PTEN downregulation in PTEN methylated CCMs in comparison to PTEN unmethylated CCMs. Reduced PTEN expression was inversely correlated to the expression of
proliferating cell nuclear antigen and to the
activation of
Erk1,2 , but not of Akt
Frost et al., Mol Cancer Ther 2009
(Multiple Myeloma...) :
However, only an
ERK inhibitor
prevented D-cyclin IRES activity in resistant `` low-AKT '' myeloma cells
Wang et al., Neurosci Lett 2009
:
Cell-cycle regulators such as
cyclin dependent kinase 2 (Cdk2) , Cyclin D1 and Hes1
mediated the effect of
Erk on NSCs proliferation and differentiation
Song et al., Biochim Biophys Acta 2010
(MAP Kinase Signaling System) :
We further show that IKKalpha dependent downregulation of Cyclin D1 expression in the UVB response results from the reduction of
ERK1/2 dependent
Cyclin D1 transcription coupled with an increase of p38 kinase dependent Cyclin D1 proteolysis
Siejka et al., Prostate 2010
(Prostatic Hyperplasia) :
We also measured by Western blot the influence of GHRH and GHRH antagonist JMR-132 on the expression of the
PCNA and the
activation of
ERK1/2 and JAK/STAT3
Groehler et al., J Cell Biol 2010
(Genomic Instability) :
We now show that
ERK8 ( extracellular signal regulated kinase 8 ) is
required for
PCNA protein stability
Li et al., J Basic Microbiol 2013
:
The
ERK1/2-specific inhibitor significantly
blocked the increased expression in Egr-1 and
PCNA induced by coccoid H. pylori
Sensui et al., Dev Biol 2012
(Calcium Signaling...) :
GST-dN85-cyclin , which maintains Cdk1 activity,
caused ERK activity in the eggs to persist for over 120 min after fertilization, and prolonged [ Ca ( 2+ ) ] ( i ) oscillations