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IL10 — NOTCH2
Text-mined interactions from Literome
Benson et al., Eur J Immunol 2005
:
Notch1 co-localizes with CD4 on activated T cells and
Notch signaling is
required for
IL-10 production ... In addition, the finding that
Notch signaling is
required for production of
IL-10 may allude to a role in immune regulation
Rutz et al., Proc Natl Acad Sci U S A 2008
(Hypersensitivity, Delayed) :
Notch regulates
IL-10 production by T helper 1 cells ... Here, we show that
Notch induces
IL-10 production in newly developing and already established Th1 cells via a signal transducer and activator of transcription 4 ( STAT4 ) -dependent process ... Our data suggest that
Notch regulates
IL-10 production in Th1 cells by a STAT4 dependent process that converts proinflammatory Th1 cells into T cells with regulatory activity
Zhang et al., J Biol Chem 2012
(Inflammation...) :
Importantly, overexpression of constituted active form of Notch1 ( NICD1 ) and
Notch2 ( NICD2 ) suppressed production of TLR4 triggered proinflammatory cytokines such as TNF-a and IL-6 but
promoted production of antiinflammatory cytokine
IL-10 , which is dependent on the PEST domain of NICD