Gene interactions and pathways from curated databases and text-mining

◀ Back to MAPK8

MAP3K7 — MAPK8

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK8 → MAP3K7 (increases, MAP3K7 Activity, MAPK8 Activity)
    Evidence: The IRAK4:IRAK1:TRAF6 complex then interacts at the membrane with another preformed complex consisting of TAK1, TAB1 and TAB2. This interaction induces phosphorylation of TAB2 and TAK1. TAK1 is subsuequently activated in the cytoplasm, leading to the activation of IKK. Activation leads to phosphorylation and degradation of IKB and consequent release of NFKB. Activation of TAK1 also results in the activation of MAP kinases and JNK.
  • OpenBEL Selventa BEL large corpus: MAPK8 → MAP3K7 (increases, MAP3K7 Activity, MAPK8 Activity)
    Evidence: In IRAK1-deficient mice, cytokine production in response to IL-1 and LPS was diminished but not abolished25-27, whereas IRAK4-deficient mice showed virtually no response to IL-1, LPS or other bacterial components, demonstrating that IRAK4 has an important role in IL-1R/TLR signalling28. Recently, patients with an inherited IRAK4 deficiency have been identified29. These patients failed to respond to IL-1, to IL-18 or to stimulation of each of five TLRs (TLR2, TLR3, TLR4, TLR5 and TLR9). Together,...
  • KEGG NOD-like receptor signaling pathway: Complex of MAP3K7-TAB1-TAB2-TAB3 → MAPK10/MAPK8/MAPK9 (protein-protein, activation)
  • KEGG Toxoplasmosis: MAP3K7 → MAPK10/MAPK8/MAPK9 (protein-protein, activation)
  • WikiPathways EBV LMP1 signaling: Complex of MAP3K7-TAB1-MAP3K3-TRAF6 → MAPK8 (activation)
  • WikiPathways NLR Proteins: MAP3K7 → MAPK8 (activation)
  • WikiPathways DNA Damage Response (only ATM dependent): Complex of MAP3K4-MAP3K7 → MAPK8 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Goswami et al., Dev Biol 2001 (MAP Kinase Signaling System) : Overexpression of TAK1 led to a reduction in MAPK activity in early gastrula ectoderm
McDermott et al., J Biol Chem 2002 : In addition we found a role for TAK-1 in the activation of p38 MAPK by IL-1, with TAK-1 also associating with active Ras
Kettner-Buhrow et al., Biochem Biophys Res Commun 2006 (MAP Kinase Signaling System) : dsiRNA against TAK1 or TAB1 significantly suppressed their target proteins as well as TAK1 mediated activation of NFkappaB, p38 MAPK , and JNK, and of IL-8 transcription
Kim et al., American journal of physiology. Renal physiology 2007 : TGF-beta activated kinase 1 and TAK1 binding protein 1 cooperate to mediate TGF-beta1 induced MKK3-p38 MAPK activation and stimulation of type I collagen ... Transient overexpression of TAK1 with TAB1 enhanced the activation of MKK3 and p38 MAPK with or without TGF-beta(1) stimulation, whereas a dominant negative mutant of TAK1 ( TAK1DN ) suppressed TGF-beta(1) induced activation of MKK3 and p38 MAPK
Windheim et al., Biochem J 2007 : We also show that RIP2 induces the activation of the protein kinase TAK1 ( transforming-growth-factor-beta activated kinase-1 ), that a dominant negative mutant of TAK1 inhibits RIP2 induced activation of JNK ( c-Jun N-terminal kinase ) and p38alpha MAPK , and that signalling downstream of NOD2 or RIP2 is reduced by the TAK1 inhibitor ( 5Z ) -7-oxozeaenol or in TAK1-deficient cells
Adhikari et al., Oncogene 2007 : Stimulation of cells with cytokines and microbial pathogens results in the activation of TAK1 , which subsequently activates the I-kappa B kinase complex (IKK) and mitogen activated protein ( MAP ) kinases , culminating in the activation of NF-kappaB and AP-1, respectively
Kodym et al., RNA 2008 (MAP Kinase Signaling System) : Activation of TAK1-D leads to the downstream activation of the p38 MAPK and of SAPK/JNK but not the NFkappaB pathway
Kumar et al., J Immunol 2009 (Inflammation) : In this study, we tested the hypothesis that TAK1 ( TGF-beta activated kinase 1 ) is involved in TWEAK induced activation of NF-kappaB and MAPK and expression of proinflammatory protein
Mikkelsen et al., J Biol Chem 2009 : We also observed that TRAF2 and TAK1 were essential for RIG-I mediated activation of p38 MAPK
Korchnak et al., Cell Signal 2009 : Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase ( MAP3K ) that activates multiple mitogen activated protein kinase ( MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Cheng et al., J Biomed Mater Res A 2010 (Inflammation...) : The critical role for TAK1 in p38MAPK and NFkappaB activation was as well confirmed by the inhibition of p38MAPK and NFkappaB activity following 5Z-7-oxozeaenol, a selective inhibitor of TAK1
Qian et al., J Immunol 2011 (Parkinson Disease) : Salmeterol significantly inhibited LPS induced production of microglial proinflammatory neurotoxic mediators, such as TNF-a, superoxide, and NO, as well as the inhibition of TAK1 mediated phosphorylation of MAPK and p65 NF-?B
Avila et al., Innate Immun 2012 : Lyn kinase controls TLR4 dependent IKK and MAPK activation modulating the activity of TRAF-6/TAK-1 protein complex in mast cells
Tran et al., J Biol Chem 2012 (MAP Kinase Signaling System) : In agreement with this, overexpression of ASK1 or TAK1 resulted in enhanced p38MAPK activation, and their knockdown inhibited p38MAPK in C2C12 cells ... Overexpression of TAK1 or ASK1 in Cdo ( -/- ) myoblasts and Cdo depleted C2C12 cells restored p38MAPK activation as well as myotube formation
Yumoto et al., J Biol Chem 2013 (Cleft Palate) : Our studies show that in neural crest derived craniofacial ecto-mesenchymal cells, Tak1 is not only required for TGF-ß- and bone morphogenetic protein induced p38 Mapk activation but also plays a role in agonist induced C-terminal and linker region phosphorylation of the receptor mediated R-Smads
Hirata et al., J Immunol 2013 : TAK1 , a member of MAPK kinase kinase ( MAPKK-K ) family, can activate JNK, p38 MAPK , and NF-?B signaling pathways