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MAPK8 — PRKD1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK8 → PRKD1 (increases, PRKD1 Activity, MAPK8 Activity)
  Evidence: Growth factors and cytokines within the BM microenvironment (ie, IL-6 and VEGF) mediate MM-cell growth, survival, and drug resistance....enzastaurin inhibited PKCu/PKD activation triggered by these stimuli...Furthermore, serum isolated from MM patient BM strongly triggered Thr-514 phosphorylation as well as activation of downstream signaling molecules including MARCKS, JNK, and c-Myc...enzastaurin strongly inhibited seruminduced phosphorylation of catalytic Thr-514 PKC and downstream signaling m...

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PRKD1 — MAPK8 (physical association, affinity chromatography technology) Hurd et al., Oncogene 2002*
• IRef Hprd Interaction: PRKD1 — MAPK8 (in vivo) Hurd et al., Oncogene 2002*

Text-mined interactions from Literome

Hausser et al., FEBS Lett 2001 : Here we show that human protein kinase C mu (PKC mu) activates the mitogen activated protein kinase ( MAPK )
El Khattabi et al., Mol Endocrinol 2013 : Furthermore the expression of alanine ( A ) 134-MafA, but not A57-MafA, reduced the oxidative stress mediated loss of glucose stimulated insulin secretion, which was independent of p38 MAPK action on protein kinase D , a regulator of insulin secretion