◀ Back to IRF3

IRF3 — IRF4

Pathways - manually collected, often from reviews:

• BioCarta the information processing pathway at the ifn beta enhancer: IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1) → IRF (IRF5/IRF1/IRF3/IRF6/IRF7/IRF4/IRF2) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  

Text-mined interactions from Literome

Nehyba et al., Mol Cell Biol 2002 : The expression of IRF-10 is induced by the oncogene v-rel, the proto-oncogene c-rel, and IRF-4 in a tissue-specific manner
Hemmi et al., J Exp Med 2004 (Virus Diseases) : Viral infection and stimulation with lipopolysaccharide (LPS) or double stranded RNA ( dsRNA ) induce phosphorylation of interferon ( IFN ) regulatory factor ( IRF)-3 and its translocation to the nucleus, thereby leading to the IFN-beta gene induction
Bibeau-Poirier et al., J Immunol 2006 (Virus Diseases) : In agreement with this observation, IRF-3 is recruited to Cullin1 following virus infection and overexpression of a dominant negative mutant of Cullin1 significantly inhibits the degradation of IRF-3 observed in infected cells
Daffis et al., J Virol 2008 (Viremia...) : In cell culture, many RNA viruses trigger IFN responses through the binding of RNA recognition molecules ( RIG-I, MDA5, and TLR-3 ) and induction of interferon regulatory factor IRF-3 dependent gene transcription
Sweeney et al., J Immunol 2010 (Arthritis, Rheumatoid) : IRF3 regulates IFN stimulated response element ( ISRE ) promoter activity as well as IFN-beta, IRF5 , IRF7, RANTES, IFN-inducible protein-10, MCP-1, and MIP1alpha gene expression in response to poly ( I-C )