◀ Back to IL12A
CD4 — IL12A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Sin et al., J Immunol 1999
:
IL-12 gene as a DNA vaccine adjuvant in a herpes mouse model :
IL-12 enhances Th1-type
CD4+ T cell mediated protective immunity against herpes simplex virus-2 challenge
Carter et al., J Exp Med 1999
:
In response to antigen, CD8 ( + ) T cells can produce IFN-gamma independently of IL-12, whereas
CD4 ( + ) T cells
require IL-12 and Stat4 activation
McRae et al., Blood 2000
:
In addition, IFN-alpha/beta treated DC secreted less
IL-12 upon
stimulation with Staphylococcus aureus Cowan strain or with
CD4 ( + ) T cells, and this decrease correlated directly with their inability to support CD4 ( + ) T-cell secretion of IFN-gamma, even though T-cell lymphotoxin production was unaffected
Young et al., AIDS Res Hum Retroviruses 2001
(HIV Seropositivity) :
IL-12 increased cell recovery in cultures of PBMC from HIV-seropositive individuals with
CD4 counts > 500 cells/microl and also increased the precursor CTL frequency
Martin et al., Infect Immun 2001
:
In a coculture system, CT-treated
CD4 ( + ) T cells
induced significantly less TNF-alpha and
IL-12 p70 production by both autologous monocytes and monocyte derived dendritic cells than either LT-IIa- or LT-IIb treated CD4 ( + ) T cells
Del Río et al., Infect Immun 2001
(Disease Models, Animal...) :
The lack of
IL-12 resulted in few infiltrating
CD4 ( + ) T cells in the liver relative to the number in WT mice, although the number of CD8 ( + ) T cells was slightly higher
Iwasaki et al., Eur J Immunol 2001
(Calcium Signaling) :
A critical role for
IL-12 in CCR5 induction on T cell receptor
triggered mouse
CD4 ( + ) and CD8 ( + ) T cells
Shaw et al., Infect Immun 2002
(Chlamydia Infections) :
Immunity generated by infection or ex vivo antigen pulsed DC correlates with a chlamydia-specific
interleukin 12 (IL-12) dependent
CD4 ( + ) Th1 immune response
Yoo et al., J Immunol 2002
:
These results suggest that PI3K/Akt pathway is critical for mediating
IL-12 induced
CD4 ( + ) T cell responses such as T cell proliferation and survival
Pan et al., Mol Ther 2002
(Colonic Neoplasms...) :
The results demonstrated that OX40 ligation of
CD4 ( + ) T cells facilitated the development of primary and memory CTL responses against tumorcells and that coordinated immune activation by
IL-12 , anti-4-1BB, and anti-OX40
resulted in a significantly higher survival rate in mice with large tumor burdens
Soumelis et al., Springer Semin Immunopathol 2004
(Hypersensitivity...) :
TSLP activated human DCs produce Th2 attracting chemokines but no
IL-12 , and
induce naive
CD4 ( + ) and CD8 ( + ) T cell differentiation into effector cells with a typical pro-allergic phenotype
Tazaki et al., Cell Immunol 2004
(Asthma) :
Significant increases in the expression of IL-12R beta2 chain before and after
stimulation of
CD4 ( + ) T cells with
IL-12 or IFN-gamma were observed in RIT treated patients compared with that in control patients
Li et al., Cancer Res 2005
(Fibrosarcoma) :
IL-12 and IL-18
stimulated CD4 ( + ) TDLN cells and enhanced IFNgamma production by CD4 ( + ) cells to a greater extent than by CD8 ( + ) cells
Gruber et al., Cancer Gene Ther 2005
(Philadelphia Chromosome...) :
We found that
IL-12 was able to eliminate pre established leukemia, and that this protection was
mediated by
CD4 , CD8, and NK cells in combination
King et al., J Immunol 2005
:
Cutting edge :
IL-12 induces
CD4+CD25- T cell activation in the presence of T regulatory cells
Wells et al., J Allergy Clin Immunol 2007
(Inflammation...) :
Adoptive transfer of transgenic antigen-specific CD8, but not
CD4 , cells
resulted in increased
IL-12 levels and reduced IL-13 and IL-5 levels in bronchoalveolar lavage fluid, coupled with substantially reduced airway eosinophilia after repeated allergen inhalation, a process mimicked by intranasal administration of IL-12 and inhibited by anti-IL-12 antibody
Pakpour et al., J Immunol 2008
(Leishmaniasis, Cutaneous) :
In this study, we show that the Leishmania-specific central memory
CD4 ( + ) T cells
require IL-12 to produce IFN-gamma, demonstrating that this population needs additional signals to develop into Th1 cells
Iborra et al., Microbes Infect 2008
(Leishmaniasis, Cutaneous) :
This protection was associated with the induction of an
IL-12 dependent specific-IFN-gamma response
mediated mainly by
CD4 ( + ) T cell, albeit a minor contribution of CD8 ( + ) T cells can not be ruled out
Brahmachari et al., J Immunol 2009
:
IL-12p40 ( 2 ) dose-dependently
inhibited the expression of Foxp3 and CD25, but not
CD4
Hamza et al., International journal of molecular sciences 2010
:
IL-12 induces interferon-gamma (IFN-gamma) production and
triggers CD4 ( + ) T cells to differentiate into type 1 T helper ( Th1 ) cells
Abdi et al., Scand J Immunol 2010
:
Moreover, antigen activated
CD4 ( + ) T cells from wild type or IFN-?-deficient mice both
initiated IL-12p75 production from DCs
Ramer-Tait et al., Cell Immunol 2011
(Leishmaniasis, Cutaneous) :
Neutralization of IL-2 enhanced
CD4 ( + ) T cell proliferation in
response to
IL-12
Ma et al., Blood 2012
:
We previously found that IL-12 mediates the differentiation of human CD4 ( + ) T cells to the Tfh lineage, because
IL-12 induces naive human
CD4 ( + ) T cells to acquire expression of IL-21, BCL6, ICOS, and CXCR5, which typify Tfh cells
Zhong et al., Blood 2012
(Purpura, Thrombocytopenic, Idiopathic) :
Th-1 polarizing cytokine
IL-12 , secreted after direct contact of patient T-cell and CD16 ( + ) monocytes, was responsible for the inhibitory
effect on Treg and IL-17 ( + )
CD4 ( + ) cell proliferation
Cargnelutti et al., Immunol Cell Biol 2013
:
In addition, we found that
CD4 ( + ) T cells from TNFRp55 ( -/- ) mice
controlled antigen-specific
IL-12/23 ( p40 ) production in recipient WT mice
Rahim et al., J Immunol 2013
(Melanoma, Experimental) :
Furthermore, Ly49Q expression on pDC, but not myeloid dendritic cells, is necessary for optimal
IL-12 secretion, MHC-II expression,
activation of
CD4 ( + ) T cell proliferation, and nuclear translocation of the master IFN-a regulator IFN regulatory factor 7 in response to TLR9 agonists
Nastala et al., J Immunol 1994
(Adenocarcinoma...) :
These results indicate that
IL-12 is an effective and minimally toxic antitumor agent in murine tumor models and
leads to an immune mediated rejection involving, at least in part, IFN-gamma,
CD4+ , and CD8+ cells
Bianchi et al., J Immunol 1996
(Hypersensitivity, Delayed...) :
In vitro and in vivo cell depletion experiments suggested the following : 1 ) the exogenous
IL-12 required both
CD4+ and CD8+ cells for activity ; 2 ) the immune response initiated by IL-12 relied on later production of IL-12 by the host ; and 3 ) the early adjuvanticity of the exogenous IL-12 involved improved recognition of class II-restricted epitopes of this otherwise poorly immunogenic tumor peptide
Maruo et al., J Immunol 1997
:
IL-12 production was
dependent on the presence of
CD4+ , but not of CD8+, T cells, and inhibited by addition of anti-CD40 ligand (CD40L) mAb
Flynn et al., J Exp Med 1998
:
Furthermore, T cell stimulation through OX40 inhibits IFN-gamma expression in both CD8 T cells and
IL-12 stimulated
CD4 T cells
Harada et al., Cancer Res 1998
(Melanoma, Experimental) :
The in vivo depletion of either
CD4+ or CD8+ T cells abrogated the antitumor activity of IL-12 and
diminished the apparent autocrine stimulation of
IL-12 release seen after IL-12 treatment
Suzuki et al., J Virol 1999
:
Among them,
interleukin-12 (IL-12) and IL-4
induce naive
CD4 ( + ) T cells to become T-helper 1 ( Th1 ) or Th2 cells, respectively