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EPO — NOS3

Text-mined interactions from Literome

Wang et al., Hypertension 1999 : EPO resulted in a dose dependent inhibition of basal and acetylcholine stimulated NO production and eNOS protein expression and also led to a significant dose dependent stimulation of DNA synthesis in endothelial cells ... The inhibitory effects of EPO on NO production and eNOS expression were reversed by felodipine ... The suppressive effects of EPO on NO production and on eNOS expression are reversed by calcium channel blockade
Rui et al., Cardiovasc Res 2005 (Myocardial Reperfusion Injury) : An AP-1 `` decoy '' oligonucleotide prevented the induction of eNOS by EPO and reversed the beneficial effect of EPO
Desai et al., Lab Invest 2006 (Atherosclerosis...) : In vitro studies revealed that EPO reduces ecNOS expression at both the protein and mRNA levels and that EPO also mediates a reduction in ecNOS enzymatic activity
Urao et al., Circ Res 2006 (Hyperplasia...) : Epo induced Akt/eNOS phosphorylation and NO synthesis on EPCs and exerted an antiapoptotic action on wire injured arteries
Burger et al., Cardiovasc Res 2006 (Myocardial Ischemia...) : EPO increases eNOS expression and NO production in cardiomyocytes
Santhanam et al., Acta Pharmacol Sin 2006 (Vasospasm, Intracranial) : In this review, we discuss the EPO induced activation of endothelial nitric oxide ( NO ) synthase and its contribution to the prevention of cerebral vasospasm
Zhang et al., Zhonghua Xin Xue Guan Bing Za Zhi 2008 : The effects of EPO on eNOS and NO could be blocked by LY294002
Aoshiba et al., Crit Care Med 2009 (Disease Models, Animal...) : Erythropoietin also reduced inducible nitric oxide synthase expression, nitric oxide production, peroxynitrite formation, and tissue hypoxia
Mihov et al., Am J Physiol Cell Physiol 2009 : Erythropoietin activates nitric oxide synthase in murine erythrocytes
Wen et al., Zhonghua Xin Xue Guan Bing Za Zhi 2009 : EPO also activated Akt and enhanced the expression of eNOS and its phosphorylation ( all P < 0.05 ), increased the NO production ( P < 0.01 )
Carraway et al., Circ Res 2010 : We examined the hypothesis that EPO receptor (EpoR) ligand binding, which activates endothelial NO synthase (eNOS) , regulates the prosurvival program of mitochondrial biogenesis in the heart
Contaldo et al., Shock 2011 : Erythropoietin requires endothelial nitric oxide synthase to counteract TNF-[alpha ] -induced microcirculatory dysfunction in murine striated muscle
Su et al., J Cell Physiol 2012 : AMP activated protein kinase mediates erythropoietin induced activation of endothelial nitric oxide synthase ... We investigated whether AMP activated protein kinase (AMPK), a multi-functional regulator of energy homeostasis, participates in the regulation of erythropoietin (EPO) mediated activation of endothelial nitric oxide synthase (eNOS) in endothelial cells ( ECs ) and mice ... Inhibition of AMPK activation by compound C or dominant negative AMPK mutant abrogated the EPO induced increase in the phosphorylation of AMPK, ACC, and eNOS , as well as nitric oxide ( NO ) production
Oba et al., Int J Urol 2012 (Reperfusion Injury) : Erythropoietin significantly stimulated phosphorylation of Akt and endothelial nitric oxide synthase in the kidneys
Adelibieke et al., Circ J 2013 : Indoxyl sulfate suppressed EPO induced survival/proliferation, anti-apoptosis function, phosphorylation of endothelial nitric oxide synthase , and the expression of thrombospondin-1, an erythroid stimulating factor, in HUVECs
Coldewey et al., Kidney Int 2013 : In the kidneys of endotoxemic wild-type mice, EPO enhanced the phosphorylation of Akt, glycogen synthase kinase-3ß, and endothelial nitric oxide synthase , and inhibited the activation of nuclear factor-?B
López Ongil et al., Exp Nephrol 1996 : Recombinant human erythropoietin does not regulate the expression of endothelin-1 and constitutive nitric oxide synthase in vascular endothelial cells