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JAK2 — KLK3

Text-mined interactions from Literome

Wakioka et al., Leukemia 1999 : Therefore, one of the major functions of APS is in recruitment of c-Cbl into the receptor/JAK complex, thereby inhibiting JAK signaling activity
O'Brien et al., J Biol Chem 2002 : These results suggest that 1 ) SH2-B beta specifically activates JAK2, 2 ) APS negatively regulates both JAK2 and JAK1, and 3 ) both SH2-B beta and APS may serve as adapter proteins for all three JAKs independent of any role they have in JAK activity
Nishi et al., Mol Cell Biol 2005 : SH2-B or APS homodimerization and SH2-B/APS heterodimerization thus provide direct mechanisms for activating and inhibiting JAK2 and other kinases from the inside of the cell and for potentiating or attenuating cytokine and growth factor receptor signaling when ligands are present
Kurzer et al., Mol Cell Biol 2006 : Binding of APS to a phosphotyrosine 813 independent site inhibits JAK2 ... Together, our data suggest that SH2-Bbeta and APS do not activate JAK2 as a consequence of their own dimerization, recruitment of an activator of JAK2, or direct competition with a JAK2 inhibitor for binding to JAK2