Itagaki et al., Gut 2005
:
Oestradiol inhibited ROS generation and antioxidant enzyme loss via the suppression of NADH/NADPH oxidase activity, and attenuated hydrogen peroxide induced transforming growth factor-beta1 ( TGF-beta1 ) expression, HSC proliferation and transformation, and the activation of mitogen activated protein kinase ( MAPK ) pathways and transcription factors
Hong et al., Hepatology 2009
(Liver Cirrhosis) :
Extracellular signal regulated kinase 1/2 and phosphoinositide 3-kinase pathways mediate SDF-1alpha induced effects on HSC expression of collagen I and proliferation