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ROCK1 — SOX9

Text-mined interactions from Literome

Woods et al., J Biol Chem 2005 : RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis ... We show that pharmacological inhibition of ROCK signaling by Y27632 resulted in increased glycosaminoglycan synthesis and elevated expression of the chondrogenic transcription factor Sox9 , whereas overexpression of RhoA in the chondrogenic cell line ATDC5 had the opposite effects
Woods et al., J Biol Chem 2006 : This is illustrated by a decrease in the transcript levels of collagen II and aggrecan as well as reduced activity of a Sox9-responsive reporter gene in response to ROCK inhibition and cytochalasin D
Haudenschild et al., Arthritis Rheum 2010 : In vitro, ROCK directly phosphorylated SOX9 at Ser ( 181 ), and the overexpression of ROCK or the activation of the RhoA pathway in SW1353 chondrosarcoma cells increased SOX9 ( Ser181 ) phosphorylation ... ROCK caused a dose dependent increase in the transcription of a SOX9-luciferase reporter construct, and increased phosphorylation and nuclear accumulation of SOX9 protein in response to transforming growth factor beta treatment and mechanical compression