Tokairin et al., Pathol Int 2008
(Down Syndrome...) :
A recent report indicated that OPN could directly activate the HSC ... Thus, it is suggested that OPN produced by hepatocytes and macrophages induces activation of the HSC , and leads to the development of perisinusoidal liver fibrosis
Xiao et al., Dig Dis Sci 2012
(Liver Cirrhosis) :
The present study was designed to investigate the expression of OPN in liver tissues and plasma of cirrhotic patients and further explore the role of OPN in human hepatic stellate cell (HSC) activation