◀ Back to SPP1
GIP — SPP1
Text-mined interactions from Literome
Lyssenko et al., Diabetes 2011
(Diabetes Mellitus, Type 2) :
Pleiotropic
effects of
GIP on islet function involve
osteopontin
Omar et al., Biochem Biophys Res Commun 2012
:
Regulation of the pro-inflammatory cytokine
osteopontin by
GIP in adipocytes -- a role for the transcription factor NFAT and phosphodiesterase 3B ... In this work we show that
GIP stimulates lipogenesis and
osteopontin expression in primary adipocytes ... The
GIP induced increase in
osteopontin expression was inhibited by the NFAT ( the transcription factor nuclear factor of activated T-cells ) inhibitor A-285222 ... To test whether cAMP might be involved in
GIP mediated effects on
osteopontin a number of strategies were used ... In summary, we delineate mechanisms by which
GIP stimulates
osteopontin in adipocytes
Ahlqvist et al., Diabetes 2013
(Insulin Resistance) :
Since glucose dependent insulinotropic polypeptide ( GIP ) is a strong stimulator of adipogenesis and may play a role in the development of obesity, we explored whether
GIP directly would
stimulate OPN expression in adipose tissue and thereby induce insulin resistance ...
GIP stimulated
OPN protein expression in a dose dependent fashion in rat primary adipocytes