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TP53 — VHL

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: VHL — TP53 (physical association, affinity chromatography technology) Roe et al., Mol Cell 2006*
• IRef Biogrid Interaction: VHL — TP53 (direct interaction, pull down) Roe et al., Mol Cell 2006*
• IRef Biogrid Interaction: VHL — TP53 (physical association, affinity chromatography technology) Lai et al., J Proteome Res 2011

Text-mined interactions from Literome

Galbán et al., Mol Cell Biol 2003 (Carcinoma, Renal Cell...) : Influence of the RNA binding protein HuR in pVHL regulated p53 expression in renal carcinoma cells ... Taken together, our findings support a role for pVHL in elevating p53 expression, implicate HuR in enhancing VHL mediated p53 translation, and suggest that VHL mediated p53 upregulation may contribute to pVHL 's tumor suppressive functions in renal cell carcinoma
Roe et al., Mol Cell 2006 : Here we found that pVHL directly associates with and stabilizes p53 by suppressing Mdm2 mediated ubiquitination and nuclear export of p53
Roe et al., Cell cycle (Georgetown, Tex.) 2006 (Cell Transformation, Neoplastic...) : The positive regulation of p53 by the tumor suppressor VHL ... Recently, we found that pVHL directly associates and positively regulates the tumor suppressor p53 by inhibiting Mdm2 mediated ubiquitination, and by subsequently recruiting p53 modifying enzymes
Ampofo et al., Int J Biochem Cell Biol 2010 : Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1alpha mediated transcription