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MAPK3 — MATK
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zagozdzon et al., Cell Signal 2006
(MAP Kinase Signaling System) :
Csk homologous kinase (CHK) , unlike Csk,
enhances MAPK activation via Ras mediated signaling in a Src independent manner ... Exogenous expression of wild-type CHK, but not Csk or a dead-kinase mutant of
CHK ,
resulted in enhanced
Erk1/2 phosphorylation in PC12 cells ... However,
stimulation of
Erk1/2 activation by
CHK was independent of the NGF stimulation or the inhibition of Src kinase by CHK ... Down-regulation of the expression of endogenous
CHK by RNAi in PC12 cells
led to a significant decrease in
MAPK activation following NGF stimulation
Poehlmann et al., Pathol Res Pract 2010
(Neoplasms) :
Importantly, as current evidence also suggests a role of MAPK 's ( mitogen activated protein kinases ) in cell cycle checkpoint control, we describe in this review both the
ATR/ATM-Chk1/Chk2 signaling pathways as well as the
regulation of cell cycle checkpoints by
MAPK 's as molecular mechanisms in DDR, and how their dysfunction is related to cancer development
Dai et al., Blood 2011
(MAP Kinase Signaling System...) :
These findings suggest that Src kinase is required for
Chk1-inhibitor mediated Ras
ERK1/2 signaling
activation , and that disruption of this event sharply potentiates the anti-MM activity of Chk1 inhi-bitors in vitro and in vivo