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IRS1 — PTEN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of GRB2-IRS1 → PTEN (decreases, GRB2/IRS1 Activity) Weng et al., Hum Mol Genet 2001*
  Evidence: The latter was accompanied by a decrease in the phosphorylation of insulin receptor substrate 1 (IRS-1) and the association of IRS-1 with Grb2/Sos
• OpenBEL Selventa BEL large corpus: IRS1 → PTEN (decreases, PTEN Activity, IRS1 Activity) Weng et al., Hum Mol Genet 2001*
  Evidence: Modified assertion
• OpenBEL Selventa BEL large corpus: IRS1 → PTEN (decreases, IRS1 Activity) Weng et al., Hum Mol Genet 2001*
  Evidence: The latter was accompanied by a decrease in the phosphorylation of insulin receptor substrate 1 (IRS-1) and the association of IRS-1 with Grb2/Sos

Text-mined interactions from Literome

Nakashima et al., J Biol Chem 2000 (MAP Kinase Signaling System) : Further, insulin induced phosphorylation of downstream targets Akt and p70S6 kinase were also inhibited significantly by overexpression of PTEN , whereas tyrosine phosphorylation of the insulin receptor and IRS-1 or the phosphorylation of mitogen activated protein kinase were not affected , suggesting that the Ras/mitogen activated protein kinase pathway remains fully functional
Qin et al., Horm Metab Res 2009 (Disease Models, Animal...) : Quantitative real-time PCR assays showed that CE treatment decreased the mRNA expression of IL-1beta, IL-6 and TNF-alpha, improved the mRNA expression of IR, IRS1 , IRS2, PI3K and Akt1, inhibited CD36, MTTP, and PTEN , and enhanced the impaired SREBP-1c expression in TNF-alpha treated enterocytes
Qin et al., Mol Nutr Food Res 2010 (Body Weight...) : In the myocardium, GTP also increased the insulin receptor (Ir), insulin receptor substrate 1 and 2 ( Irs1 and Irs2 ), phosphoinositide-3-kinase (Pi3k), v-akt murine thymoma viral oncogene homolog 1 ( Akt1 ), glucose transporter 1 and 4 ( Glut1 and Glut4 ) and glycogen synthase 1 (Gys1) expression but inhibited phosphatase and tensin homolog deleted on chromosome ten ( Pten ) expression and decreased glycogen synthase kinase 3beta ( Gsk3beta ) mRNA expression
Clément et al., Hepatology 2011 (Carcinoma, Hepatocellular...) : PTEN down-regulation promoted in turn a reduction of insulin receptor substrate 1 (IRS1) expression