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ESR1 — LEP
Text-mined interactions from Literome
Machinal-Quélin et al., Endocrine 2002
:
Altogether, these results suggest that the sexual dimorphism of leptinemia in humans is mainly owing to the
estrogen receptor dependent stimulation of
leptin expression in adipose tissue by estrogens and estrogen precursors in women
Catalano et al., J Biol Chem 2004
(Disease Progression...) :
Using a dominant negative ERK2 or the MAPK inhibitor PD 98059, we showed that
leptin activates the
ERalpha through the MAPK pathway
Garofalo et al., Clin Cancer Res 2004
(Breast Neoplasms) :
Leptin effects on
estrogen receptor alpha dependent transcription in the presence and absence of ICI 182,780 were studied by luciferase reporter assays and chromatin immunoprecipitation
Yu et al., Endocrinology 2008
(Metabolic Diseases...) :
Further examination showed that androgen-AR signaling in adipose tissue
plays a direct regulatory role in
leptin expression via enhanced
estrogen receptor transactivation activity due to elevated intraadipose estrogens
Koda et al., Folia Histochem Cytobiol 2007
(Breast Neoplasms) :
In vitro investigations showed
leptin mediated escalation of estrogen synthesis and boosted activity of estrogen receptor
ERalpha
Hirosawa et al., Biochem Biophys Res Commun 2008
(Diabetes Mellitus...) :
These results indicate that
ERalpha plays an essential role in
leptin- and insulin stimulated upregulation of the POMC gene
Yu et al., Chin Med J (Engl) 2010
(Breast Neoplasms) :
This study examined the
effects of exogenous human
leptin on
estrogen receptor (ER) alpha and beta in human breast tumor tissue in a nude mouse xenograft model
Li et al., Cytokine 2013
:
Stage specific
effect of
leptin on the expressions of
estrogen receptor and extracellular matrix in a model of chondrocyte differentiation