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BRAF — EGF

Text-mined interactions from Literome

Antonelli et al., Mol Biol Cell 2000 : In Chinese hamster ovary cells, EGF receptors activate B-Raf but not Raf-1 or A-Raf
Guan et al., J Biol Chem 2000 : Furthermore, expression of Akt inhibits epidermal growth factor induced B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo
Piiper et al., Mol Pharmacol 2000 : In contrast, PTx, CCK, and EGF had only minor effects on A-Raf and B-Raf activity
Kanno et al., Hepatology 2002 (Bile Duct Neoplasms...) : Epidermal growth factor (EGF) immediately and transiently stimulated Raf-1 activity, whereas B-Raf activity was increased with prolonged EGF stimulation ... EGF stimulated Raf-1 and B-Raf activities were both inhibited by UK14,304
Yamaguchi et al., Kidney Int 2003 (MAP Kinase Signaling System...) : We determined the effects of cAMP and epidermal growth factor (EGF) on the activation of ERK, B-Raf and Raf-1 in ADPKD and HKC cells by immune kinase assay and Western blot
Yoon et al., Biochemistry (Mosc) 2004 : The addition of SB203580 prolonged the transient activation of both B-Raf and ERK by EGF alone
Ren et al., Proc Natl Acad Sci U S A 2007 : Our data identify a previously unrecognized interaction between IQGAP1 and B-Raf and suggest that IQGAP1 is a scaffold necessary for activation of B-Raf by EGF
Yamaguchi et al., American journal of physiology. Renal physiology 2010 (Polycystic Kidney, Autosomal Dominant) : We found that nanomolar concentrations of Sorafenib reduced the basal activity of ERK, inhibited cAMP dependent activation of B-Raf and MEK/ERK signaling, and caused a concentration dependent inhibition of cell proliferation induced by cAMP, epidermal growth factor , or the combination of the two agonists
Vaillancourt et al., Mol Cell Biol 1994 : In response to epidermal growth factor , nerve growth factor, and platelet derived growth factor, B-Raf and Raf-1 are activated, phosphorylate recombinant kinase-inactive MEK-1, and activate wild-type MEK-1
Lange-Carter et al., Science 1994 : Activation of MEKK and B-Raf in response to EGF was inhibited by expression of dominant negative N17Ras ... Stimulation of synthesis of cyclic adenosine 3',5'-monophosphate abolished activation of MEKK and B-Raf by EGF , NGF, and TPA
Walker et al., Mol Cell Biol 1998 : Analysis of the early signalling events by the WT, V741G, and Y740F mutant EGF receptors indicated that EGF stimulates comparable levels of Shc phosphorylation, Shc-GRB-2 association, and activation of Ras, B-Raf , and Erk-1