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MLST8 — ULK2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database mTOR signaling pathway:
mTORC1 complex (MTOR-MLST8-RPTOR)
→
mTORC1/ULK1-2/ATG13/FIP200 complex (MTOR-MLST8-RPTOR-ULK1_ULK2-ATG13-RB1CC1)
(modification, collaborate)
Hosokawa et al., Mol Biol Cell 2009, Jung et al., Mol Biol Cell 2009, Ganley et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
mTORC1 complex (MTOR-MLST8-RPTOR)
→
ULK1-2/ATG13/FIP200 complex (ULK1_ULK2-ATG13-RB1CC1)
(modification, collaborate)
Hosokawa et al., Mol Biol Cell 2009, Jung et al., Mol Biol Cell 2009, Ganley et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
mTORC1/ULK1-2/ATG13/FIP200 complex (MTOR-MLST8-RPTOR-ULK1_ULK2-ATG13-RB1CC1)
→
ULK1-2/ATG13/FIP200 complex (ULK1_ULK2-ATG13-RB1CC1)
(modification, collaborate)
Hosokawa et al., Mol Biol Cell 2009, Jung et al., Mol Biol Cell 2009, Ganley et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Jung et al., Mol Biol Cell 2009
:
ULK-Atg13-FIP200 complexes
mediate mTOR signaling to the autophagy machinery ... These findings demonstrate that the
ULK-Atg13-FIP200 complexes are direct targets of mTOR and important regulators of autophagy in
response to
mTOR signaling
Dunlop et al., Autophagy 2011
:
Interestingly,
ULK1 overexpression also increases phosphorylation of Raptor Ser863 and the mTOR autophosphorylation site, Ser2481 in a
mTORC1 dependent manner
Jung et al., Autophagy 2011
:
In addition,
ULK1 was found to bind raptor, induce its phosphorylation, and
inhibit the kinase activity of
mTORC1