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EPHB2 — SMCP
Text-mined interactions from Literome
Yang et al., J Cell Biol 2004
(Melanoma) :
Expression of
MCSP enhances integrin mediated cell spreading, FAK phosphorylation, and activation of
ERK1/2 ... Enhanced
activation of FAK and
ERK1/2 by
MCSP appears to involve independent mechanisms because inhibition of FAK activation had no effect on ERK1/2 phosphorylation
Yang et al., Cancer Res 2009
(MAP Kinase Signaling System...) :
MCSP expression in melanoma cells
enhances integrin function and constitutive activation of
Erk1,2 ... The results show that
MCSP expression in radial growth phase, vertical growth phase, or metastatic cell lines
causes sustained activation of
Erk1,2 , enhanced growth, and motility which all require the cytoplasmic domain of the MCSP core protein