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Text-mined interactions from Literome
York et al., Mol Cell Biol 2000
:
PI3-K and endocytosis may also regulate ERK signaling at a second site downstream of Ras, since both rapid
ERK activation and the Ras dependent
activation of the MAP kinase kinase kinase
B-Raf are blocked by inhibition of either PI3-K or endocytosis
Mikula et al., EMBO J 2001
:
MEK/ERK activation is normal in Raf-1-deficient cells and embryos, and is probably
mediated by
B-RAF
Nadal-Wollbold et al., FEBS Lett 2002
:
Platelet
ERK2 activation by thrombin is
dependent on calcium and conventional protein kinases C but not Raf-1 or
B-Raf
Yamaguchi et al., J Biol Chem 2004
(Polycystic Kidney Diseases) :
In M-1 cells, we showed that calcium restriction was associated with an elevation in
B-Raf protein levels and cAMP stimulated, Ras dependent
activation of B-Raf and
ERK
Tanami et al., Oncogene 2004
(Melanoma...) :
Not only downregulation of the endogenously overexpressed wild-type
B-Raf by antisense oligonucleotide but also a treatment with an inhibitor of mitogen activated protein kinase kinase ( MAPKK, MEK )
reduced phosphorylated
ERK1/2 and cell growth, whereas the exogenously expressed wild-type B-Raf promoted cell growth in MM cells
Dwivedi et al., Mol Psychiatry 2006
(MAP Kinase Signaling System) :
Our results of selective reduction in catalytic activity and expression of B-Raf but not Raf-1 suggest that
B-Raf may be
playing an important role in altered
ERK signaling in brain of suicide subjects, and thus in the pathophysiology of suicide
Sétáló et al., Neurochem Res 2005
:
While direct activation of PKC mimicked the effect of estrogen on ERK, both in pattern of activation and resulting intraneuronal distribution of ERK, PKC induced
ERK phosphorylation
required the activity of MEK but not
B-Raf
Yue et al., Dev Neurobiol 2008
:
Artificial
Erk activation by expression of constitutively active Mek1 and
B-Raf failed to block ephrin-A5 effects on growth cones, and inhibitors of the Erk pathway also failed to inhibit collapse by ephrin-A5
Vuchak et al., Mol Pharmacol 2009
(MAP Kinase Signaling System) :
Silencing the expression of
B-Raf also
inhibited ERK activation by TSH, forskolin, and 6MB-cAMP, but not that stimulated by insulin or serum
Yamaguchi et al., American journal of physiology. Renal physiology 2010
(Polycystic Kidney, Autosomal Dominant) :
We found that nanomolar concentrations of Sorafenib reduced the basal activity of
ERK ,
inhibited cAMP dependent activation of
B-Raf and MEK/ERK signaling, and caused a concentration dependent inhibition of cell proliferation induced by cAMP, epidermal growth factor, or the combination of the two agonists
Satoh et al., PloS one 2012
(Genetic Predisposition to Disease...) :
However, ( T599A )
B-RAF did not destabilize the inactive conformation of the B-RAF kinase, and did not
induce increased
ERK phosphorylation or C-RAF transactivation
Bonfiglio et al., Mol Endocrinol 2013
:
B-Raf and CRHR1 Internalization
Mediate Biphasic
ERK1/2 Activation by CRH in Hippocampal HT22 Cells
Hong et al., Exp Cell Res 2013
(MAP Kinase Signaling System...) :
Using androgen deprived LNCaP cells, in which ERK1/2 activation occurs in strong correlation with AKT activation, we found that AKT mediated
B-Raf regulation is
necessary for
ERK1/2 activation