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ASIP — CASP5

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Nomura et al., Toxicol Lett 1998 (Ischemic Attack, Transient) : In addition, a NO donor ( NOC18 ) -induced apoptosis was inhibited by Z-Asp-CH2-DCB , a caspase inhibitor , in SH-SY5Y cells
Watanabe et al., J Cell Physiol 1999 : Z-Asp-CH2-DCB ( Z-Asp ), a general caspase inhibitor , blocked cell spreading on collagen coated plates in a dose dependent manner but did not affect cell viability ... The caspase 3-like activity was significantly inhibited by Z-Asp
Harada et al., Jpn J Pharmacol 1999 : Z-Asp-CH2-DCB , a caspase inhibitor with anti-apoptotic activity, did not inhibit the induction and phosphorylation of c-Jun
Kim et al., Toxicology 2000 : Both Asp-Glu-Val-Asp-aldehyde ( DEVD-cho ) and Tyr-Val-Ala-Asp-chloromethylketone ( YVAD-cmk ), selective inhibitors of caspase-3 and caspase-1 , respectively, suppressed significantly cadmium induced cell death
Humphreys et al., J Biol Chem 2000 : Asp-Glu-Val-Asp-cho , a caspase-3 inhibitor , inhibited ATP induced DNA fragmentation and alpha-fodrin proteolysis, but had no effect on ATP induced SAPK activation
Blanchard et al., J Mol Biol 2000 : We report the X-ray crystallographic structure of caspase-8 in complex with benzyloxycarbonyl-Asp-Glu-Val-Asp-aldehyde ( Z-DEVD ), a specific group II caspase inhibitor
Zhang et al., Clin Exp Immunol 2000 : Pretreatment of eosinophils with benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ( Z-VAD.FMK ), a broad-spectrum caspase inhibitor , could inhibit dexamethasone induced apoptosis in eosinophils dose-dependently
Shibuya et al., Hepatology 2000 (Liver Diseases) : We encapsulated and used Z-Asp , a caspase inhibitor in poly-N-p-vinylbenzyl-D-lactonamide ( PVLA ) coated-poly ( L-lactic acid ) ( PLA ) -nanospheres in a mouse model of acute hepatitis
Rasola et al., J Immunol 2001 : Interestingly, the peptide Z-Val-Ala-DL-Asp-fluoromethylketone ( a broad-spectrum caspase inhibitor ) reduces, but does not abolish, phosphatidylserine exposure, suggesting that Nef also activates a caspase independent apoptotic pathway
Suzuki et al., J Immunol 2001 (Inflammation) : The cleavage of both molecules was inhibited by G-CSF and benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone , a caspase inhibitor , both of which can inhibit neutrophil apoptosis
Schmidt et al., J Immunol 2001 : In contrast, the caspase inhibitor N : -acetyl-Asp-Glu-Val-Asp-aldehyde suppressed caspase-3 activation and apoptosis, but did not down-regulate caspase-8 activation and expression of CD95 and CD95L
Kennedy et al., Cancer Lett 2001 (Carcinoma, Ehrlich Tumor) : Inhibiting the activation of caspase-3 with acetyl-Asp-Glu-Val-Asp-alpha-aldehyde ( caspase inhibitor ) caused a reversal in the effect on cell viability
Petit et al., J Biol Chem 2002 : Treatment with benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone , a broad spectrum caspase inhibitor , prevented nuclear chromatin condensation and fragmentation in HIV infected CD4+ T cells and in a cell-free system ( in which nuclei were incubated with cytoplasmic extracts from the HIV infected CD4+ T cells )
Wosikowski et al., Cancer Res 2002 (Leukemia, Monocytic, Acute) : Induction of apoptosis was prevented by bongkrekic acid, Z-Asp-Glu-Val-Asp-fluoromethylketone , and Z-Leu-Glu-His-Asp-fluoromethylketone, inhibitors of the mitochondrial permeability transition and of caspase 3 and 9, respectively, but not by Ac-Tyr-Val-Ala-Asp-CHO, a specific caspase 1 inhibitor, suggesting the involvement of the permeability transition pore, caspase 3, and caspase 9 in the WK175 induced apoptotic cascade
Huigsloot et al., J Biol Chem 2002 (Mammary Neoplasms, Animal) : Benzyloxycarbonyl-Val-Ala-dl-Asp-fluoromethylketone also blocked activation of caspase-8 , thus excluding an involvement of the death receptor pathway in Deltapsi dissipation
Nabha et al., Clin Cancer Res 2002 (Leukemia, Lymphocytic, Chronic, B-Cell) : However, the addition of Z-Val-Ala-Asp-fluoromethylketone ( a general caspase inhibitor ) or Z-Leu-Glu ( OMe ) -His-Asp ( OMe ) -CH2F ( a caspase 9 inhibitor ) before CA4P treatment did not block cell death
López et al., Br J Pharmacol 2003 (Necrosis) : ( 2 ) Our results indicate that : ( 1 ) cadmium is taken up by the neurons in a dose and serum dependent way ; ( 2 ) cadmium, at concentrations from 1 micro M or 10 micro M ( depending on the absence or the presence of serum ) up to 100 micro M, decreases the metabolic capacity, which was evaluated by the XTT ( tetrazolium salt ) test ; ( 3 ) cadmium induces apoptosis and LDH ( lactate dehydrogenase ) release in a dose dependent way ; ( 4 ) in a serum-free medium, the cadmium induced apoptosis is accompanied by caspase-3 activation ; ( 5 ) both the caspase-3 activation and the cadmium induced apoptosis are reversed by N-acethyl-Asp-Glu-Val-Asp-aldehyde ( Ac-DEVD-CHO ), a selective caspase-3 inhibitor , indicating that the caspase-3 pathway is involved in cadmium induced apoptosis in cortical neurons ; and ( 6 ) the cadmium concentrations which produce caspase-3 activation do not modify the intracellular ATP levels ; however, higher cadmium concentrations lead to both intracellular ATP depletion and ATP release, but do not increase the caspase-3 activity, indicating that cadmium also produces cellular death by necrosis
Ceruti et al., Mol Pharmacol 2003 (Astrocytoma) : Moreover, the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-dl-Asp-fluoromethylketone ( fmk ) suppressed both caspase-3 activation and apoptosis induction
Yamamoto-Yamaguchi et al., Anticancer Res 2003 (Lung Neoplasms) : The expression of Apo2.7, an early apoptotic change, is also induced by this combined treatment, and is suppressed by the addition of Z-Asp-CH2-DCB , a pan caspase inhibitor
Song et al., J Immunol 2004 (MAP Kinase Signaling System) : We demonstrate that CO inhibited caspase-3 and caspase-8 expression and activity, and caspase inhibition with benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ( Z-VAD-FMK pan-caspase inhibitor ) blocked T lymphocyte proliferation
Wu et al., Mol Cancer Ther 2004 (Cholangiocarcinoma) : The celecoxib induced cell death was significantly blocked by N-benzyloxy-carbonyl-Val-Ala-Asp-fluoromethylketone , a wide-spectrum caspase inhibitor
Iizuka et al., Radiat Res 2005 : Addition of benzyloxycarbonyl-val-ala-asp-fluoromethylketone ( Z-VAD-FMK ), a broad-spectrum caspase inhibitor , attenuated the increased lethality, but the dose-response curve obtained was found to merely revert to that obtained for cells exposed to X rays alone
Arechiga et al., J Immunol 2005 : Pretreatment with benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone , a potent caspase inhibitor , also failed to impede canonical NF-kappaB signaling
Araki et al., Cell Biol Int 2006 : Caspase activity increased with the addition of DIDS to serum deprived MCT cells, but Z-Asp-CH2-DCB , a caspase inhibitor , did not inhibit cell death in DIDS treated, serum deprived MCT cells
Huelsenbeck et al., Infect Immun 2007 : The cytotoxic effect of TcdB was executed by caspase-3, as it was responsive to inhibition by acetyl-Asp-Met-Gln-Asp-aldehyde ( Ac-DMQD-CHO ), an inhibitor of caspase-3
Kuo et al., Toxicol Lett 2008 (Adenocarcinoma...) : Denbinobin induced caspase 3 activation, and N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ( zVAD-fmk ), a broad-spectrum caspase inhibitor , prevented denbinobin induced cell death
Li et al., Zhonghua Yi Xue Za Zhi 2008 (Dermatitis, Allergic Contact...) : To investigate the effects of N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ( Z-VAD-FMK ), a broad caspase inhibitor , on allergic contact dermatitis (ACD)
Atar et al., Neuroscience 2010 (Deafness...) : In order to rescue the hair cells in the knockout mice, we produced explant cultures from mouse cochleae at an early embryonic stage and treated the cells with z-Val-Ala-Asp-fluoromethylketone ( z-VAD-fmk ), a general caspase inhibitor
Mohamed et al., Ann Anat 2010 (Aneurysm...) : To investigate apoptotic modulation, caspase-3 was inhibited by N-acetyl-Asp-Glu-Val-Asp-CHO ( Ac-DEVD-CHO )
Li et al., Zhonghua Yi Xue Za Zhi 2012 (Dermatitis, Allergic Contact) : To explore the effects of N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ( Z-VAD-FMK ), a broad caspase inhibitor , on the elicitation of murine allergic contact dermatitis (ACD) and examine the effects on T lymphocytes
Sawai et al., Biochem Biophys Res Commun 2013 (Necrosis) : TNF induced caspase-3 activity was completely inhibited by Z-VAD-fmk, Z-DEVD-fmk, or Z-Asp-CH2-DCB ... These results suggest that the partial activation of caspase-8 in the presence of Z-Asp-CH2-DCB may suppress TNF induced necroptosis via the cleavage of RIP1, and also suggest that Z-Asp-CH2-DCB, but not Z-DEVD-fmk, may be used as a caspase-3-specific inhibitor in cells
Lee et al., Toxicon 2013 : In addition, pretreatment with Z-Val-Ala-Asp-fluoromethylketone ( Z-VAD-fmk ), a broad spectrum caspase inhibitor , could not rescue apoptotic cells from ClpP toxicity
Geley et al., Oncogene 1997 (Leukemia-Lymphoma, Adult T-Cell) : p53 dependent apoptosis was preceded by digestion of poly ( ADP-ribose ) polymerase, a typical target of interleukin-1beta converting enzyme ( ICE ) -like proteases/caspases, and was markedly resistant to the ICE/caspase-1 and FLICE/caspase-8 inhibitor acetyl-Tyr-Val-Ala-Asp.chloromethylketone ( YVAD ), but sensitive to the CPP32/caspase-3 inhibitor benzyloxycarbonyl-Asp-Glu-Val-Asp.fluoromethylketone ( DEVD ) and benzyloxycarbonyl-Val-Ala-Asp.fluoromethylketone ( zVAD ), a caspase inhibitor with broader specificity
Lin et al., Am J Physiol 1998 : Furthermore, pretreatment of HL-60 cells with N-acetyl-Asp-Glu-Val-Asp-aldehyde , a specific inhibitor of caspase-3 , but not N-acetyl-Tyr-Val-Ala-Asp-aldehyde, a specific inhibitor of caspase-1, decreased peroxynitrite induced apoptosis
Hsu et al., Proc Assoc Am Physicians 1998 (Rothmund-Thomson Syndrome) : Treatment of the RTS cell line with acetyl-Asp-Glu-Val-Asp-aldehyde ( Ac-DEVD-CHO ), a specific inhibitor of caspase-3 , significantly increased the cell viability after CH-11 treatment ( 75.9 % +/- 2.2 % )
Bradham et al., Mol Cell Biol 1998 : In contrast, Asp-Glu-Val-Asp-cho , an inhibitor of caspase 3, did not block depolarization or onset of the MPT induced by TNFalpha, although it inhibited cell death completely
Panvichian et al., Cancer Res 1998 : The multimininucleated phenotype could be mimicked in HeLa cells treated with paclitaxel and benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone ( z-VAD-fmk ), a peptide caspase inhibitor
Guo et al., Exp Cell Res 1998 : Complete inhibition of cell death was achieved with benzyloxycarbonyl-Val-Ala-Asp-fluromethylketone, a peptide inhibitor of the caspase protease family, and Z-Asp-Glu-Val-Asp-FMK , a specific inhibitor of caspase-3 ... Both Acetyl-Tyr-Val-Ala-Asp-chloromethylketone and Acetyl-Tyr-Val-Ala-Asp-aldehyde , selective caspase-1 ( interleukin-1beta converting enzyme ) inhibitors , exerted only partial protection of cells from apoptosis at higher concentrations
Araya et al., FEBS Lett 1998 (Neuroblastoma) : Pretreatment with Z-Asp-CH2-DCB , a caspase inhibitor , suppressed the DNA ladder in response to hypoxia in a concentration dependent manner
Miyashita et al., Cell Death Differ 1998 (Leukemia, B-Cell) : Here we report that Bcl-2 and benzyloxycarbonyl-Val-Ala-Asp ( OMe ) -fluoromethylketone ( zVAD-fmk ), a broad spectrum caspase inhibitor , prevent loss of mitochondrial membrane potential ( delta psi m ) and the production of reactive oxygen species ( ROS ) caused by GC, while acetyl-Asp-Glu-Val-Asp-aldehyde ( Ac-DEVD-CHO ), an inhibitor of the caspase-3 family proteases, does not