RodrÃguez et al., Clin Exp Immunol 2007
(Malnutrition...) :
Moreover, leptin enhanced the expression of CD69 and CD25 on CD4 ( + ) and CD8 ( + ) cells after stimulation with PMA-ionomycin
Liu et al., J Immunol 2012
(Genetic Predisposition to Disease...) :
Leptin also inhibits CD4 ( + ) CD25 ( + ) Foxp3 ( + ) regulatory T cells, which are known to contribute significantly to the mechanisms of peripheral immune tolerance