Gene interactions and pathways from curated databases and text-mining

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LEP — LPL

Text-mined interactions from Literome

Thomas et al., Endocrinology 1999 : Leptin increased mRNA levels of lipoprotein lipase at 3 days, but decreased mRNA levels of adipsin and leptin at 9 days and decreased lipid droplet formation by 50 %
Bulló et al., Int J Obes Relat Metab Disord 2002 (Diabetes Mellitus...) : These include the inhibitory effect on LPL activity, the mediation on glucose homeostasis or the effect on leptin
Maingrette et al., Diabetes 2003 (Arteriosclerosis...) : Leptin increases lipoprotein lipase secretion by macrophages : involvement of oxidative stress and protein kinase C
Wang et al., Zhongguo Zhen Jiu 2005 : Electroacupuncture can improve the status of high blood lipids, increase lipoprotein lipase activity, and regulate serum leptin and insulin levels in the obestic rat
Li et al., Sheng Wu Gong Cheng Xue Bao 2008 : The results showed that 100 nmol/L leptin up-regulated the mRNA expression of ATGL, TGH-2, HSL, MGL and LPL ( P < 0.01 ), but down-regulated the Perilipin mRNA expression ( P < 0.01 ). At the same time, leptin promoted the glycerol release in a dose dependent manner ( P < 0.01 ), but had no effect on the FFA release ( P > 0.05 )
Nyrén et al., BMC physiology 2012 : We conclude that both LPL and GPIHBP1 are present in mouse pancreas, and that LPL expression in beta cells is dependent on leptin
Ranganathan et al., Endocrinology 1998 : The effect of leptin on glucose transport, lipogenesis, and lipoprotein lipase activity was studied in cultured rat adipocytes and 3T3-L1 adipocytes ... Lipoprotein lipase (LPL) activity remained unchanged in response to leptin in these cells, as well as in minced adipose tissue
Scarpace et al., Am J Physiol 1998 : These data indicate that the leptin induction of UCP1 gene expression in BAT is dependent on sympathetic innervation but that the leptin induction of LPL gene expression is not