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POLDIP2 — TLR4

Text-mined interactions from Literome

Cuschieri et al., J Surg Res 2004 : LPS stimulation led to the mobilization of TLR4 to lipid rafts followed by phosphorylation and activation of IRAK, ERK 1/2, p38 , and JNK/SAPK
Yan et al., Life Sci 2007 (Fever) : Further experiments confirmed that TLR4 ligation activates extracellular signal regulated kinase ( ERK ), p38 , and nuclear factor-kappaB pathways more potently in DCs pretreated with 39.5 degrees C
Zhou et al., World J Gastroenterol 2008 (Adenocarcinoma...) : Viable LBG or LBG- ( s ) pretreatment attenuated the expression of TLR4 , inhibited the phosphorylation of TAK1 and p38MAPK , prevented the activation of NF-kappaB, and consequently blocked IL-8 production
Xiang et al., J Int Med Res 2009 : LPS induced SR-A expression on RAW264.7 was completely suppressed by the p38-specific inhibitor, SB203580, but not by inhibition of toll-like receptor 4 (TLR4) signalling with MTS510, demonstrating that p38- but not TLR4 dependent up-regulation of SR-A was involved in endotoxin tolerance through binding and internalization of LPS
Chen et al., Toxicology 2009 (Neovascularization, Pathologic) : The mechanism revealed that wogonoside inhibited LPS induced toll-like receptor 4 (TLR4) up-regulation and its downstream mitogen activated protein kinases ( MAPKs ) activation, by decreasing the phosphorylation of c-Jun N-terminal kinase (JNK), extracellular signal regulated kinase ( ERK ) and p38 mitogen activated protein kinase