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CASP7 — E2F1

Pathways - manually collected, often from reviews:

• NCI Pathway Database E2F transcription factor network: E2F1/DP complex (E2F1-TFDP2_TFDP1) → Caspase 7 (CASP7) (transcription, activates) Nahle et al., Nat Cell Biol 2002
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Lee et al., Mol Cells 2002 : After UV-irradiation the level of E2F1 in E7-expressing astrocytes was higher than E6-, LXSN- or mock infected cells, and caspase-3 was activated to a greater extent
Duxbury et al., Clin Cancer Res 2004 (Adenocarcinoma...) : PP2 augmented gemcitabine induced caspase mediated apoptosis, suppressed RRM2 expression, and decreased activity of the RRM2 regulating transcription factor E2F1 in PANC1 ( GemRes )
Afshar et al., Cancer Res 2006 (Glioma) : In a system of inducible E2F1 activity, E2F1 activated caspase-8 and, accordingly, decreased cellular viability, effects that were abolished by caspase-8 siRNA ... In a system of inducible E2F1 activity, E2F1 activated caspase-8 and, accordingly, decreased cellular viability, effects that were abolished by caspase-8 siRNA